Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect - Takasu, Keiko; Yawata, Yosuke; Tashima, Ryoichi; Aritomi, Hiroyuki; Shimada, Shinji; Onodera, Tsukasa; Taishi, Teruhiko; Ogawa, Koichi (Frontiers in cellular neuroscience, 2024)
Keywords: Allosteric properties; Amygdala; antidepressant-like effect; Antidepressants; benzodiazepine; Benzodiazepines; Brain research; Cellular Neuroscience; Cellulose; Diazepam; EEG; extrasynaptic GABAA receptor; Interneurons; Laboratory animals; Mental depression; Molecular modelling; Neural networks; neuroactive steroid; Neuromodulation; Neurosteroids; Oscillations; Patients; Postpartum depression; Prefrontal cortex; Pregnanolone; social defeat stress model; Social interaction; Social interactions; Steroid hormones; Steroids; theta activity; γ-Aminobutyric acid A receptors; United States--US; Japan; social defeat stress model; antidepressant-like effect; basolateral amygdala; benzodiazepine; extrasynaptic GABAA receptor; neuroactive steroid; theta activity