Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment

• Published in: Cell communication and signaling Vol. 21; no. 1; pp. 190 - 24
• Main Authors: Dai, Yalan, Zhang, Xinyi, Ou, Yingjun, Zou, Linglin, Zhang, Duoli, Yang, Qingfan, Qin, Yi, Du, Xiuju, Li, Wei, Yuan, Zhanpeng, Xiao, Zhangang, Wen, Qinglian
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.08.2023; BMC
• Subjects: Anoikis; Anoikis resistance; Apoptosis; Binding sites; Breast cancer; Cell adhesion & migration; Cell death; Cytoskeleton; ECM detachment; Epidermal growth factor; Extracellular matrix; Intracellular signalling; Kinases; Ligands; Medical prognosis; Metastases; Metastasis; Mitochondria; Phenotypes; Phosphorylation; Physiology; Proteins; Review; Signal transduction; Tumors; Anoikis; Anoikis resistance; Breast cancer; ECM detachment

Breast cancer exhibits the highest global incidence among all tumor types. Regardless of the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of apoptosis initiated by cell detachment from the native environment, is an outside-in process commencing with the dis...