Genomic characterization of clonal evolution during oropharyngeal carcinogenesis driven by human papillomavirus 16

• Published in: BMB reports Vol. 51; no. 11; pp. 584 - 589
• Main Authors: Chae, Jeesoo, Park, Weon Seo, Kim, Min Jung, Jang, Se Song, Hong, Dongwan, Ryu, Junsun, Ryu, Chang Hwan, Kim, Ji-Hyun, Choi, Moon-Kyung, Cho, Kwan Ho, Moon, Sung Ho, Yun, Tak, Kim, Jong-Il, Jung, Yuh-Seog
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society for Biochemistry and Molecular Biology 01.11.2018; 생화학분자생물학회
• Subjects: Carcinogenesis - genetics; Carcinogenesis - pathology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - virology; Case-Control Studies; Cell Transformation, Viral - genetics; Cell Transformation, Viral - physiology; Clonal Evolution - genetics; DNA Copy Number Variations; DNA Mutational Analysis - methods; Female; Gene Frequency; Genome-Wide Association Study; Genomics; Human papillomavirus 16 - physiology; Humans; Middle Aged; Mouth Mucosa - pathology; Mouth Mucosa - virology; Oropharyngeal Neoplasms - genetics; Oropharyngeal Neoplasms - pathology; Oropharyngeal Neoplasms - virology; Sequence Analysis, DNA; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - virology; 화학

Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven c...