Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation

• Published in: Stem cells and development Vol. 25; no. 2; p. 114
• Main Authors: Shum, Laura C, White, Noelle S, Mills, Bradley N, Bentley, Karen L de Mesy, Eliseev, Roman A
• Format: Journal Article
• Language: English
• Published: United States 15.01.2016
• Subjects: Bone Marrow Cells - cytology; Cell Differentiation - physiology; Cell Proliferation - physiology; Cells, Cultured; Energy Metabolism - physiology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Mesenchymal Stem Cells - metabolism; Mitochondria - metabolism; Osteogenesis - physiology

There is emerging interest in stem cell energy metabolism and its effect on differentiation. Bioenergetic changes in differentiating bone marrow mesenchymal stem cells (MSCs) are poorly understood and were the focus of our study. Using bioenergetic profiling and transcriptomics, we have established...