Amplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer's disease from tear fluid

• Published in: Nature communications Vol. 14; no. 1; p. 8153
• Main Authors: Lee, Sojeong, Kim, Eunjung, Moon, Chae-Eun, Park, Chaewon, Lim, Jong-Woo, Baek, Minseok, Shin, Moo-Kwang, Ki, Jisun, Cho, Hanna, Ji, Yong Woo, Haam, Seungjoo
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 09.12.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Adenylate cyclase; Alzheimer Disease - metabolism; Alzheimer's disease; Amplification; Amyloid beta-Peptides; Biomarkers; Biomarkers - metabolism; Biopsy; Diagnosis; Early Diagnosis; Humans; Immunoassay; Long-term care; Monitoring; Nanoparticles; Neurodegenerative diseases; Proteomics; Reproducibility of Results; Self-assembly; Signs and symptoms; Telemedicine

Accurate diagnosis of Alzheimer's disease (AD) in its earliest stage can prevent the disease and delay the symptoms. Therefore, more sensitive, non-invasive, and simple screening tools are required for the early diagnosis and monitoring of AD. Here, we design a self-assembled nanoparticle-media...