Exploring potential working mechanisms of accelerated HF-rTMS in refractory major depression with a focus on locus coeruleus connectivity

• Published in: European psychiatry Vol. 67; no. 1; p. e70
• Main Authors: Wu, Guo-Rong, Baeken, Chris
• Format: Journal Article
• Language: English
• Published: England Cambridge University Press 17.10.2024
• Subjects: accelerated rTMS; Adult; Antidepressants; Brain research; Brain-derived neurotrophic factor; Clinical outcomes; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - therapy; Depressive Disorder, Treatment-Resistant - physiopathology; Depressive Disorder, Treatment-Resistant - therapy; Dorsolateral Prefrontal Cortex; Drug therapy; Electric fields; Electroconvulsive therapy; Female; Humans; locus coeruleus; Locus Coeruleus - physiopathology; Magnetic Resonance Imaging; major depressive disorder; Male; Mental depression; Middle Aged; Neurobiology; Neurogenesis; Prefrontal Cortex - physiopathology; Psychotropic drugs; Transcranial Magnetic Stimulation - methods; Treatment Outcome; major depressive disorder; locus coeruleus; accelerated rTMS

This study investigates the effects of accelerated high-frequency repetitive transcranial magnetic stimulation (aHF-rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC), on locus coeruleus (LC) functional connectivity in the treatment of refractory medication-resistant major depression...