Marine Origin Polysaccharides in Drug Delivery Systems

Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical appl...

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Bibliographic Details
Published inMarine drugs Vol. 14; no. 2; p. 34
Main Authors Cardoso, Matias J, Costa, Rui R, Mano, João F
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2016
MDPI
Subjects
Algae
Alginic acid
Animals
Anti-inflammatory agents
Aquatic Organisms - metabolism
Biocompatibility
Biodegradability
Biodegradation
Biological properties
Biomaterials
Biomedical materials
Carrageenan
Chemical compounds
Chemistry, Pharmaceutical - methods
Chitosan
Construction materials
Controlled release
Costs
Delayed-Action Preparations
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems
Drug Design
Drugs
Exploitation
External stimuli
Fucoidan
Gene transfer
Gene Transfer Techniques
Humans
Hyaluronic acid
Hydrogels
Inflammation
Marine animals
Marine biology
marine excipients
Medicine
Oceans
Oceans and Seas
pH effects
Pharmacology
polysaccharide/drug conjugates
Polysaccharides
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
Properties
Raw materials
Regenerative medicine
Regenerative Medicine - methods
Review
Saccharides
Seaweed meal
polysaccharides
polysaccharide/drug conjugates
biomaterials
drug delivery
marine excipients
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Abstract Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and extraction media, and their interaction with other biocompounds. Polysaccharides such as alginate, carrageenan and fucoidan can be extracted from algae, whereas chitosan and hyaluronan can be obtained from animal sources. Most marine polysaccharides have important biological properties such as biocompatibility, biodegradability, and anti-inflammatory activity, as well as adhesive and antimicrobial actions. Moreover, they can be modified in order to allow processing them into various shapes and sizes and may exhibit response dependence to external stimuli, such as pH and temperature. Due to these properties, these biomaterials have been studied as raw material for the construction of carrier devices for drugs, including particles, capsules and hydrogels. The devices are designed to achieve a controlled release of therapeutic agents in an attempt to fight against serious diseases, and to be used in advanced therapies, such as gene delivery or regenerative medicine.
AbstractList Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and extraction media, and their interaction with other biocompounds. Polysaccharides such as alginate, carrageenan and fucoidan can be extracted from algae, whereas chitosan and hyaluronan can be obtained from animal sources. Most marine polysaccharides have important biological properties such as biocompatibility, biodegradability, and anti-inflammatory activity, as well as adhesive and antimicrobial actions. Moreover, they can be modified in order to allow processing them into various shapes and sizes and may exhibit response dependence to external stimuli, such as pH and temperature. Due to these properties, these biomaterials have been studied as raw material for the construction of carrier devices for drugs, including particles, capsules and hydrogels. The devices are designed to achieve a controlled release of therapeutic agents in an attempt to fight against serious diseases, and to be used in advanced therapies, such as gene delivery or regenerative medicine.
Author Cardoso, Matias J
Costa, Rui R
Mano, João F
AuthorAffiliation 1 3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence of Tissue Engineering and Regenerative Medicine, Avepark—Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; matjcardoso@gmail.com
2 ICVS/3B’s, PT Government Associated Laboratory, Braga/Guimarães, Portugal
AuthorAffiliation_xml – name: 1 3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence of Tissue Engineering and Regenerative Medicine, Avepark—Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; matjcardoso@gmail.com
– name: 2 ICVS/3B’s, PT Government Associated Laboratory, Braga/Guimarães, Portugal
Author_xml – sequence: 1
  givenname: Matias J
  surname: Cardoso
  fullname: Cardoso, Matias J
  email: matjcardoso@gmail.com, matjcardoso@gmail.com
  organization: ICVS/3B's, PT Government Associated Laboratory, Braga/Guimarães, Portugal. matjcardoso@gmail.com
– sequence: 2
  givenname: Rui R
  surname: Costa
  fullname: Costa, Rui R
  email: rui.costa@dep.uminho.pt, rui.costa@dep.uminho.pt
  organization: ICVS/3B's, PT Government Associated Laboratory, Braga/Guimarães, Portugal. rui.costa@dep.uminho.pt
– sequence: 3
  givenname: João F
  surname: Mano
  fullname: Mano, João F
  email: jmano@dep.uminho.pt, jmano@dep.uminho.pt
  organization: ICVS/3B's, PT Government Associated Laboratory, Braga/Guimarães, Portugal. jmano@dep.uminho.pt
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26861358$$D View this record in MEDLINE/PubMed
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Keywords polysaccharides
polysaccharide/drug conjugates
biomaterials
drug delivery
marine excipients
Language English
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Snippet Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation...
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SubjectTerms Algae
Alginic acid
Animals
Anti-inflammatory agents
Aquatic Organisms - metabolism
Biocompatibility
Biodegradability
Biodegradation
Biological properties
Biomaterials
Biomedical materials
Carrageenan
Chemical compounds
Chemistry, Pharmaceutical - methods
Chitosan
Construction materials
Controlled release
Costs
Delayed-Action Preparations
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems
Drug Design
Drugs
Exploitation
External stimuli
Fucoidan
Gene transfer
Gene Transfer Techniques
Humans
Hyaluronic acid
Hydrogels
Inflammation
Marine animals
Marine biology
marine excipients
Medicine
Oceans
Oceans and Seas
pH effects
Pharmacology
polysaccharide/drug conjugates
Polysaccharides
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
Properties
Raw materials
Regenerative medicine
Regenerative Medicine - methods
Review
Saccharides
Seaweed meal
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Title Marine Origin Polysaccharides in Drug Delivery Systems
URI https://www.ncbi.nlm.nih.gov/pubmed/26861358
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