Dextroamphetamine Modulates the Response of the Human Amygdala

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 27; no. 6; pp. 1036 - 1040
• Main Authors: Hariri, Ahmad R, Mattay, Venkata S, Tessitore, Alessandro, Fera, Francesco, Smith, William G, Weinberger, Daniel R
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2002; Nature Publishing; Nature Publishing Group
• Subjects: Adult; Amphetamine; Amygdala; Amygdala - drug effects; Amygdala - physiology; Anxiety; Biological and medical sciences; Dextroamphetamine - pharmacology; Dopamine; Double-Blind Method; Drug toxicity and drugs side effects treatment; Emotions - drug effects; Emotions - physiology; Facial Expression; Fear; Female; Humans; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical sciences; Monoamines; Pharmacology. Drug treatments; Toxicity: nervous system and muscle; Fear; Anxiety; Dopamine; Amphetamine; Amygdala; Monoamines; Amphetamine derivatives; Human; Healthy subject; Toxicity; Magnetic resonance; Oral administration; Brain (invertebrata); Amfetamine; Mechanism of action; Brain (vertebrata)

Amphetamine, a potent monoaminergic agonist, has pronounced effects on emotional behavior in humans, including the generation of fear and anxiety. Recent animal studies have demonstrated the importance of monoamines, especially dopamine, in modulating the response of the amygdala, a key brain region...