Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells

• Published in: Stem cells and development Vol. 22; no. 14; p. 1991
• Main Authors: Lundy, Scott D, Zhu, Wei-Zhong, Regnier, Michael, Laflamme, Michael A
• Format: Journal Article
• Language: English
• Published: United States 15.07.2013
• Subjects: Action Potentials - physiology; Biomarkers - metabolism; Calcium - metabolism; Cell Differentiation; Cells, Cultured; Connexin 43 - genetics; Connexin 43 - metabolism; Embryonic Stem Cells - cytology; Embryonic Stem Cells - physiology; Gene Expression; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - physiology; Myocytes, Cardiac - cytology; Myocytes, Cardiac - physiology; Myofibrils - physiology; Myofibrils - ultrastructure; Patch-Clamp Techniques; Time Factors; Ventricular Myosins - genetics; Ventricular Myosins - metabolism

Despite preclinical studies demonstrating the functional benefit of transplanting human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) into damaged myocardium, the ability of these immature cells to adopt a more adult-like cardiomyocyte (CM) phenotype remains uncertain. To address this issue...