The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host

• Published in: Cancer and metastasis reviews Vol. 27; no. 4; pp. 691 - 705
• Main Authors: Podhajcer, Osvaldo L., Benedetti, Lorena Gabriela, Girotti, Maria Romina, Prada, Federico, Salvatierra, Edgardo, Llera, Andrea S.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2008; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cancer Research; Disease Progression; Humans; Neoplasms - metabolism; Non-Thematic Review; Oncology; Osteonectin - metabolism; Signal Transduction - physiology; Angiogenesis; Extracellular matrix; SPARC; EMT; Cancer

Tumor growth is essentially the result of an evolving cross-talk between malignant and surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This heterogeneous mass of extracellular matrix and intermingled cells interact through cell–cell and cell–matrix contacts. Malign...