The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation

There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study wa...

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Published inFrontiers in neuroscience Vol. 17; p. 1150156
Main Authors Shamloo, Shirin, Defensor, Erwin, Ciari, Peter, Ogawa, Gaku, Vidano, Laura, Lin, Jennifer S., Fortkort, John A., Shamloo, Mehrdad, Barron, Annelise E.
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 06.04.2023
Frontiers Media S.A
Subjects
Alzheimer's disease
Cytokines
Inflammasomes
Inflammation
Interleukin 1
Interleukin 10
Interleukin 18
Ischemia
Kinases
Light therapy
lipopolysaccharide (LPS)
Lipopolysaccharides
Neurodegeneration
neurodegenerative disorders
neuroinflammation
Neuroscience
photobiomodulation (PBM)
Plasma
Protein expression
Proteins
systemic inflammation
Traumatic brain injury
lipopolysaccharide (LPS)
systemic inflammation
photobiomodulation (PBM)
light therapy
neurodegenerative disorders
neuroinflammation
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Abstract There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.
AbstractList There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-minute treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1b and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.
Author Lin, Jennifer S.
Barron, Annelise E.
Shamloo, Mehrdad
Defensor, Erwin
Ogawa, Gaku
Vidano, Laura
Fortkort, John A.
Shamloo, Shirin
Ciari, Peter
AuthorAffiliation 1 Department of Bioengineering, Schools of Medicine and Engineering, Stanford University , Stanford, CA , United States
2 Department of Neurosurgery, School of Medicine, Stanford University , Stanford, CA , United States
AuthorAffiliation_xml – name: 2 Department of Neurosurgery, School of Medicine, Stanford University , Stanford, CA , United States
– name: 1 Department of Bioengineering, Schools of Medicine and Engineering, Stanford University , Stanford, CA , United States
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  surname: Ciari
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  givenname: Gaku
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37090796$$D View this record in MEDLINE/PubMed
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Copyright © 2023 Shamloo, Defensor, Ciari, Ogawa, Vidano, Lin, Fortkort, Shamloo and Barron. 2023 Shamloo, Defensor, Ciari, Ogawa, Vidano, Lin, Fortkort, Shamloo and Barron
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Keywords lipopolysaccharide (LPS)
systemic inflammation
photobiomodulation (PBM)
light therapy
neurodegenerative disorders
neuroinflammation
Language English
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This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
These authors have contributed equally to this work and share first authorship
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Snippet There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation...
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StartPage 1150156
SubjectTerms Alzheimer's disease
Cytokines
Inflammasomes
Inflammation
Interleukin 1
Interleukin 10
Interleukin 18
Ischemia
Kinases
Light therapy
lipopolysaccharide (LPS)
Lipopolysaccharides
Neurodegeneration
neurodegenerative disorders
neuroinflammation
Neuroscience
photobiomodulation (PBM)
Plasma
Protein expression
Proteins
systemic inflammation
Traumatic brain injury
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Title The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation
URI https://www.ncbi.nlm.nih.gov/pubmed/37090796
https://www.proquest.com/docview/2795859095
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https://pubmed.ncbi.nlm.nih.gov/PMC10115964
https://doaj.org/article/030edd5dba4a47a1b86d83183d76dda4
Volume 17
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