Epitope length variants balance protective immune responses and viral escape in HIV-1 infection

• Published in: Cell reports (Cambridge) Vol. 38; no. 9; p. 110449
• Main Authors: Pymm, Phillip, Tenzer, Stefan, Wee, Edmund, Weimershaus, Mirjana, Burgevin, Anne, Kollnberger, Simon, Gerstoft, Jan, Josephs, Tracy M., Ladell, Kristin, McLaren, James E., Appay, Victor, Price, David A., Fugger, Lars, Bell, John I., Schild, Hansjörg, van Endert, Peter, Harkiolaki, Maria, Iversen, Astrid K.N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022; Cell Press
• Subjects: Amino Acid Sequence; Amino Acids; Antigen Presentation; crystal structures; cytotoxic T lymphocytes; differential antigen processing; Epitopes, T-Lymphocyte; HIV Infections; HIV-1; HLA-B Antigens - genetics; HLA-B∗27:05; Humans; immune-response inhibition; KIR3DL1; Life Sciences; natural killer cells; peptide competition; Peptides; viral escape; HIV-1; natural killer cells; viral escape; HLA-B∗27:05; KIR3DL1; cytotoxic T lymphocytes; crystal structures; differential antigen processing; immune-response inhibition; peptide competition; HLA-B(∗)27:05

Cytotoxic T lymphocyte (CTL) and natural killer (NK) cell responses to a single optimal 10-mer epitope (KK10) in the human immunodeficiency virus type-1 (HIV-1) protein p24Gag are associated with enhanced immune control in patients expressing human leukocyte antigen (HLA)-B∗27:05. We find that prote...