The effects of sodium butyrate supplementation on the expression levels of PGC-1α, PPARα, and UCP-1 genes, serum level of GLP-1, metabolic parameters, and anthropometric indices in obese individuals on weight loss diet: a study protocol for a triple-blind, randomized, placebo-controlled clinical trial

• Published in: Current controlled trials in cardiovascular medicine Vol. 24; no. 1; pp. 489 - 8
• Main Authors: Amiri, Parichehr, Hosseini, Seyed Ahmad, Roshanravan, Neda, Saghafi-Asl, Maryam, Tootoonchian, Mitra
• Format: Journal Article
• Language: English
• Published: England BioMed Central 01.08.2023; BMC
• Subjects: Adolescent; Adult; Anthropometry; Appetite; Bacteria; Body composition; Body measurements; Butyric Acid - therapeutic use; Clinical trials; Consent; Data collection; Diabetes; Diet; Diet, Reducing; Dietary Supplements - adverse effects; Energy; Energy metabolism genes; Ethics; Glucagon-Like Peptide 1 - therapeutic use; Glucose; Humans; Medical research; Metabolism; Metabolites; Microbiota; Middle Aged; Nutrition research; Obesity; Obesity - diagnosis; Obesity - drug therapy; Obesity - genetics; PPAR alpha - genetics; PPAR alpha - metabolism; PPAR alpha - therapeutic use; Randomized controlled trial; Randomized Controlled Trials as Topic; Sample size; Sodium butyrate; Study Protocol; Transcription Factors; Triglycerides; Uncoupling Protein 1 - genetics; Weight control; Young Adult; Appetite; Obesity; Sodium butyrate; Randomized controlled trial; Energy metabolism genes

Obesity is a multifaceted disease characterized by an abnormal accumulation of adipose tissue. Growing evidence has proposed microbiota-derived metabolites as a potential factor in the pathophysiology of obesity and related metabolic conditions over the last decade. As one of the essential metabolit...