Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model
Congenital human cytomegalovirus (HCMV) infection may cause life-threatening disease and permanent damage to the central nervous system. The mouse model of CMV infection is most commonly used to study mechanisms of infection and pathogenesis. While essential to limit mouse CMV (MCMV) replication, th...
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Published in | Viruses Vol. 16; no. 2; p. 208 |
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Abstract | Congenital human cytomegalovirus (HCMV) infection may cause life-threatening disease and permanent damage to the central nervous system. The mouse model of CMV infection is most commonly used to study mechanisms of infection and pathogenesis. While essential to limit mouse CMV (MCMV) replication, the inflammatory responses, particularly IFNγ and TNFα, cause neurodevelopmental abnormalities. Other soluble mediators of the immune response in most tissues remain largely unexplored. To address this gap, we quantified 48 soluble mediators of the immune response, including 32 cytokines, 10 chemokines, 3 growth factors/regulators, and 3 soluble receptors in the spleen, liver, lungs, and brain at 9 and 14 days postinfection (dpi). Our analysis found 25 induced molecules in the brain at 9 dpi, with an additional 8 showing statistically elevated responses at 14 dpi. Specifically, all analyzed CCL group cytokines (CCL2, CCL3, CCL4, CCL5, CCL7, and CCL11) were upregulated at 14 dpi in the brain. Furthermore, data revealed differentially regulated analytes across tissues, such as CCL11, CXCL5, and IL-10 in the brain, IL-33/IL-33R in the liver, and VEGF-a and IL-5 in the lungs. Overall, this study provides an overview of the immune dynamics of soluble mediators in congenital CMV. |
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AbstractList | Congenital human cytomegalovirus (HCMV) infection may cause life-threatening disease and permanent damage to the central nervous system. The mouse model of CMV infection is most commonly used to study mechanisms of infection and pathogenesis. While essential to limit mouse CMV (MCMV) replication, the inflammatory responses, particularly IFNγ and TNFα, cause neurodevelopmental abnormalities. Other soluble mediators of the immune response in most tissues remain largely unexplored. To address this gap, we quantified 48 soluble mediators of the immune response, including 32 cytokines, 10 chemokines, 3 growth factors/regulators, and 3 soluble receptors in the spleen, liver, lungs, and brain at 9 and 14 days postinfection (dpi). Our analysis found 25 induced molecules in the brain at 9 dpi, with an additional 8 showing statistically elevated responses at 14 dpi. Specifically, all analyzed CCL group cytokines (CCL2, CCL3, CCL4, CCL5, CCL7, and CCL11) were upregulated at 14 dpi in the brain. Furthermore, data revealed differentially regulated analytes across tissues, such as CCL11, CXCL5, and IL-10 in the brain, IL-33/IL-33R in the liver, and VEGF-a and IL-5 in the lungs. Overall, this study provides an overview of the immune dynamics of soluble mediators in congenital CMV. |
Audience | Academic |
Author | Lisnic, Berislav Kucan Brlic, Paola Lenac Rovis, Tihana Hasan, Milena Cokaric Brdovcak, Maja Kvestak, Daria Juranic Lisnic, Vanda Karner, Dubravka |
AuthorAffiliation | 2 Cytometry and Biomarkers Unit of Technology and Service (CB TechS), Institut Pasteur, Université Paris Cité, 75015 Paris, France; milena.hasan@pasteur.fr 1 Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia; dubravka.karner@uniri.hr (D.K.); daria.kvestak@medri.uniri.hr (D.K.); berislav.lisnic@uniri.hr (B.L.); maja.cokaric@medri.uniri.hr (M.C.B.); vanda.juranic@medri.uniri.hr (V.J.L.); paola.kucan@medri.uniri.hr (P.K.B.) |
AuthorAffiliation_xml | – name: 2 Cytometry and Biomarkers Unit of Technology and Service (CB TechS), Institut Pasteur, Université Paris Cité, 75015 Paris, France; milena.hasan@pasteur.fr – name: 1 Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia; dubravka.karner@uniri.hr (D.K.); daria.kvestak@medri.uniri.hr (D.K.); berislav.lisnic@uniri.hr (B.L.); maja.cokaric@medri.uniri.hr (M.C.B.); vanda.juranic@medri.uniri.hr (V.J.L.); paola.kucan@medri.uniri.hr (P.K.B.) |
Author_xml | – sequence: 1 givenname: Dubravka orcidid: 0000-0001-8122-6113 surname: Karner fullname: Karner, Dubravka organization: Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia – sequence: 2 givenname: Daria surname: Kvestak fullname: Kvestak, Daria organization: Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia – sequence: 3 givenname: Berislav surname: Lisnic fullname: Lisnic, Berislav organization: Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia – sequence: 4 givenname: Maja surname: Cokaric Brdovcak fullname: Cokaric Brdovcak, Maja organization: Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia – sequence: 5 givenname: Vanda orcidid: 0000-0002-7182-8927 surname: Juranic Lisnic fullname: Juranic Lisnic, Vanda organization: Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia – sequence: 6 givenname: Paola orcidid: 0000-0002-9178-9128 surname: Kucan Brlic fullname: Kucan Brlic, Paola organization: Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia – sequence: 7 givenname: Milena surname: Hasan fullname: Hasan, Milena organization: Cytometry and Biomarkers Unit of Technology and Service (CB TechS), Institut Pasteur, Université Paris Cité, 75015 Paris, France – sequence: 8 givenname: Tihana orcidid: 0000-0002-3299-1334 surname: Lenac Rovis fullname: Lenac Rovis, Tihana organization: Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia |
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Keywords | cytokine chemokine MCMV congenital human cytomegalovirus infection HCMV |
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SubjectTerms | Animals Brain Brain research Central nervous system chemokine Chemokines Congenital diseases congenital human cytomegalovirus infection cytokine Cytokines Cytomegalovirus Cytomegalovirus Infections Development and progression Gene expression Growth factors HCMV Humans Immune response Immunological research Infections Inflammation Laboratory animals Liver Lymphokines MCMV Mice Monocyte chemoattractant protein 1 Muromegalovirus Neurodevelopmental disorders Pathogenesis Perinatal infection Physiological aspects Software Statistical analysis Tumor Necrosis Factor-alpha Vascular endothelial growth factor Viruses γ-Interferon |
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Title | Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model |
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