Repair of Tobacco Carcinogen-Induced DNA Adducts and Lung Cancer Risk: a Molecular Epidemiologic Study

• Published in: JNCI : Journal of the National Cancer Institute Vol. 92; no. 21; pp. 1764 - 1772
• Main Authors: Qingyi Wei, Lie Cheng, Amos, Christopher I., Wang, Li-E., Zhaozheng Guo, Hong, Waun K., Spitz, Margaret R.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 01.11.2000
• Subjects: Age Factors; Aged; Biological and medical sciences; Carcinogens - adverse effects; Case-Control Studies; Cell Line; DNA Adducts - drug effects; DNA Adducts - genetics; DNA Repair - drug effects; DNA Repair - genetics; Dose-Response Relationship, Drug; Female; Humans; Logistic Models; Lung Neoplasms - epidemiology; Lung Neoplasms - etiology; Lung Neoplasms - genetics; Lymphocytes; Male; Medical sciences; Middle Aged; Plasmids; Pneumology; Sex Factors; Smoking - adverse effects; Texas - epidemiology; Transfection; Tumors of the respiratory system and mediastinum; United States; North America; America; Texas; Human; Lung disease; Respiratory disease; Tobacco smoking; Malignant tumor; Bronchopulmonary; Carcinogen; DNA; Risk factor; Molecular epidemiology; Bronchus disease; Genetics; Repair; Public health; Molecular adduct

Background: Only a fraction of cigarette smokers develop lung cancer, suggesting that people differ in their susceptibility to this disease. We investigated whether differences in DNA repair capacity (DRC) for repairing tobacco carcinogen-induced DNA damage are associated with differential susceptib...