Assessment of Biomarkers in asbestos-exposed workers as indicators of cancer risk

• Published in: Mutation research Vol. 655; no. 1; pp. 52 - 58
• Main Authors: Amati, Monica, Tomasetti, Marco, Mariotti, Laura, Tarquini, Lucia Miria, Valentino, Matteo, Santarelli, Lory
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.08.2008; Elsevier
• Subjects: Aged; Asbestos - adverse effects; Asbestos exposure; Asbestos-exposed workers; Biological and medical sciences; Biomarkers; Biomarkers, Tumor - analysis; Biomarkers, Tumor - blood; Carcinogenic risk; Female; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Humans; Lymphocytes - metabolism; Male; Malignant mesothelioma; Medical sciences; Mesothelioma - blood; Mesothelioma - diagnosis; Mesothelioma - prevention & control; Middle Aged; Occupational Diseases - blood; Occupational Diseases - diagnosis; Occupational Diseases - prevention & control; Occupational Exposure; Pleural Neoplasms - blood; Pleural Neoplasms - diagnosis; Pleural Neoplasms - prevention & control; Regression Analysis; Risk Factors; Toxicology; Asbestos-exposed workers; Biomarkers; Malignant mesothelioma; Carcinogenic risk; Asbestos exposure; Toxicology; Asbestos; Asbestos exposure;Asbestos-exposed workers;Carcinogenic risk;Malignant mesothelioma;Biomarkers; Biological marker; Genetics; Risk; Malignant tumor; Occupational exposure; Indicator; Cancer

Epidemiological studies have shown that mortality from malignant mesothelioma (MM) and lung cancer have increased with increasing cumulative exposure to asbestos. To investigate whether tumour-related biomarkers can contribute towards the evaluation of the carcinogenic risk in populations exposed to...