Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)

• Published in: Frontiers in cellular neuroscience Vol. 17; p. 1130816
• Main Authors: Ip, Kevan L., Thomas, Monique A., Behar, Kevin L., de Graaf, Robin A., De Feyter, Henk M.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 28.04.2023; Frontiers Media S.A
• Subjects: Animal models; Brain cancer; Brain mapping; Brain research; Brain tumors; cancer; Chloride; Choline; Data acquisition; deuterium; Glioblastoma; Laboratories; metabolic imaging; Metabolism; Metabolites; Neuroimaging; Neuroscience; NMR; Nuclear magnetic resonance; Phosphocholine; Phosphorylation; Spectrum analysis; Tumors; United States > US; choline; cancer; glioblastoma; deuterium; metabolic imaging

There is a lack of robust metabolic imaging techniques that can be routinely applied to characterize lesions in patients with brain tumors. Here we explore in an animal model of glioblastoma the feasibility to detect uptake and metabolism of deuterated choline and describe the tumor-to-brain image c...