p20BAP31 induces cell apoptosis via both AIF caspase-independent and the ROS/JNK mitochondrial pathway in colorectal cancer

• Published in: Cellular & molecular biology letters Vol. 28; no. 1; pp. 25 - 22
• Main Authors: Jiang, Xiaohan, Li, Guoxun, Zhu, Benzhi, Zang, Jingnan, Lan, Tian, Jiang, Rui, Wang, Bing
• Format: Journal Article
• Language: English
• Published: England BioMed Central 28.03.2023; BMC
• Subjects: AIF; Antibodies; Apoptosis; Apoptosis Inducing Factor - metabolism; Apoptosis Inducing Factor - pharmacology; Apoptosis-inducing factor; C-Terminus; Cancer; Caspase inhibitors; Caspase-8; Caspases - metabolism; Cell cycle; Cell growth; Cell Line, Tumor; Cell proliferation; Cholecystokinin; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - metabolism; Cytochrome; Drug resistance; Endoplasmic reticulum; Flow cytometry; Humans; Immunoblotting; Immunofluorescence; JNK Mitogen-Activated Protein Kinases - metabolism; Kinases; MAP kinase; MAP Kinase Signaling System; Membrane potential; Membrane Potential, Mitochondrial; Mitochondria; Mitochondria - metabolism; Nuclear transport; p20BAP31; Plasmids; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; ROS/JNK pathway; S phase; Signal transduction; Stem cells; United States > US; China; ROS/JNK pathway; p20BAP31; AIF; Colorectal cancer; Apoptosis

During cell apoptosis, the C-terminus of BAP31 is cleaved by caspase-8 and generates p20BAP31, which has been shown to induce an apoptotic pathway between the endoplasmic reticulum (ER) and mitochondria. However, the underlying mechanisms of p20BAP31 in cell apoptosis remains unclear. We compared th...