Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus

• Published in: Clinical epigenetics Vol. 13; no. 1; p. 114
• Main Authors: Zampieri, Michele, Bacalini, Maria Giulia, Barchetta, Ilaria, Scalea, Stefania, Cimini, Flavia Agata, Bertoccini, Laura, Tagliatesta, Stefano, De Matteis, Giovanna, Zardo, Giuseppe, Cavallo, Maria Gisella, Reale, Anna
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central Ltd 17.05.2021; BioMed Central
• Subjects: ADP-ribosylation; Bisulfite; Blood cells; Case-Control Studies; Cytosine; Deoxyribonucleic acid; Development and progression; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Disease susceptibility; DNA; DNA fingerprinting; DNA methylation; DNA Methylation - genetics; DNA sequencing; Enzyme-linked immunosorbent assay; Enzymes; Epigenesis, Genetic - genetics; Epigenetic inheritance; Epigenetics; Female; Gene expression; Gene loci; Genes; Genetic aspects; Genetic research; Genomes; Genomics; Glucose metabolism; Glycosylated hemoglobin; Humans; Intermediates; Male; Mass spectrometry; Mass spectroscopy; Medical research; Medicine, Experimental; Metabolism; Methylation; Middle Aged; Peripheral blood; Physiological aspects; Poly ADP Ribosylation - genetics; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Post-translation; Post-translational modification; Pyrimidines; Regression analysis; Ribose; Sulfites; Type 2 diabetes; DNA methylation; Epigenetics; Type 2 diabetes mellitus; 5-Hydroxymethylcytosine; PARylation
• ISSN: 1868-7075; 1868-7083; 1868-7083; 1868-7075
• DOI: 10.1186/s13148-021-01099-1

Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease. Our previous studies demonstrated that the regulation of the DNA methylation pattern involves the poly(ADP-ribosyl)ation (PARylation) pro...