Increase in epicardial fat volume is associated with greater coronary artery calcification progression in subjects at intermediate risk by coronary calcium score: A serial study using non-contrast cardiac CT

• Published in: Atherosclerosis Vol. 218; no. 2; pp. 363 - 368
• Main Authors: Nakanishi, Rine, Rajani, Ronak, Cheng, Victor Y, Gransar, Heidi, Nakazato, Ryo, Shmilovich, Haim, Otaki, Yuka, Hayes, Sean W, Thomson, Louise E.J, Friedman, John D, Slomka, Piotr J, Berman, Daniel S, Dey, Damini
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.10.2011; Elsevier
• Subjects: Adipose Tissue - pathology; Aged; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; calcification; Calcinosis - pathology; calcium; Calcium - metabolism; Cardiology. Vascular system; Cardiovascular; coronary artery disease; Coronary Artery Disease - pathology; Coronary calcium score; Coronary heart disease; coronary vessels; Coronary Vessels - pathology; Disease Progression; Epicardial fat volume; Female; gender; Heart; Humans; hypertension; Male; Medical sciences; Middle Aged; multivariate analysis; odds ratio; Pericardium - pathology; Progression; Risk; risk factors; surface area; Tomography, X-Ray Computed; Treatment Outcome; epicardial fat volume; Progression; non-contrast computed tomography; CCS; EFV; EFVi; Atherosclerosis; coronary calcium score; epicardial fat volume indexed to body surface area; NCT; Coronary calcium score; Epicardial fat volume; Human; Calcium; Coronary artery; Cardiovascular disease; Inorganic element; Vascular disease; Risk factor; Calcification; Computerized axial tomography

Abstract Objective Epicardial fat volume (EFV) is related to calcified coronary plaques. However, it is unknown whether baseline EFV or changes in EFV affect the progression of coronary artery calcification over time. Methods We identified 375 consecutive asymptomatic subjects with an intermediate r...