Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model

• Published in: Nanotoxicology Vol. 9; no. 6; pp. 769 - 779
• Main Authors: Sisler, Jennifer D., Pirela, Sandra V., Friend, Sherri, Farcas, Mariana, Schwegler-Berry, Diane, Shvedova, Anna, Castranova, Vincent, Demokritou, Philip, Qian, Yong
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.01.2015
• Subjects: Air Pollutants - chemistry; Air Pollutants - toxicity; Capillaries - cytology; Capillaries - drug effects; Capillaries - immunology; Cell Line; Cell Survival - drug effects; Coculture Techniques; Cytokines - metabolism; Dose-Response Relationship, Drug; Endothelial Cells - drug effects; Endothelial Cells - immunology; Endothelial Cells - pathology; Endothelium, Vascular - drug effects; Endothelium, Vascular - immunology; Endothelium, Vascular - pathology; Epithelial Cells - drug effects; Epithelial Cells - immunology; Epithelial Cells - pathology; Humans; Laser printer emissions; Microscopy, Confocal; Microvessels - drug effects; Microvessels - immunology; Microvessels - pathology; Nanoparticles - chemistry; Nanoparticles - toxicity; nanotoxicology; occupational health; Particle Size; Printing; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - immunology; Pulmonary Alveoli - pathology; Respiratory Mucosa - blood supply; Respiratory Mucosa - drug effects; Respiratory Mucosa - immunology; Respiratory Mucosa - pathology; Surface Properties; occupational health; Laser printer emissions; nanotoxicology

The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed...