Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - A systematic review
Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evi...
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| Published in | Early human development Vol. 120; pp. 80 - 87 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
01.05.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0378-3782 1872-6232 1872-6232 |
| DOI | 10.1016/j.earlhumdev.2018.02.007 |
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| Abstract | Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE.
Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017.
Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean.
Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome.
A significant proportion of infants with mild HIE have abnormal outcome at follow up. |
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| AbstractList | Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE.
Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean.
Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome.
A significant proportion of infants with mild HIE have abnormal outcome at follow up. Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE. Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean. Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome. A significant proportion of infants with mild HIE have abnormal outcome at follow up. Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE.AIMSHypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE.Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean.METHODSMedline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean.Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome.RESULTTwenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome.A significant proportion of infants with mild HIE have abnormal outcome at follow up.CONCLUSIONA significant proportion of infants with mild HIE have abnormal outcome at follow up. |
| Author | Boylan, G.B. Murray, D.M. Conway, J.M. Walsh, B.H. |
| Author_xml | – sequence: 1 givenname: J.M. surname: Conway fullname: Conway, J.M. email: j.conway@ucc.ie organization: Irish Central for Fetal and Neonatal Translational Research-INFANT Centre, Department of Pediatrics and Child Health, University College Cork, Cork University Hospital, Wilton, Cork, Ireland – sequence: 2 givenname: B.H. surname: Walsh fullname: Walsh, B.H. email: bhwalsh@bwh.harvard.edu organization: Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA – sequence: 3 givenname: G.B. surname: Boylan fullname: Boylan, G.B. email: G.Boylan@ucc.ie organization: Irish Central for Fetal and Neonatal Translational Research-INFANT Centre, Department of Pediatrics and Child Health, University College Cork, Cork University Hospital, Wilton, Cork, Ireland – sequence: 4 givenname: D.M. surname: Murray fullname: Murray, D.M. email: D.Murray@ucc.ie organization: Irish Central for Fetal and Neonatal Translational Research-INFANT Centre, Department of Pediatrics and Child Health, University College Cork, Cork University Hospital, Wilton, Cork, Ireland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29496329$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jpeds.2010.02.016 10.1016/j.ejpn.2012.11.004 10.1542/peds.107.3.480 10.1016/j.pediatrneurol.2004.05.004 10.1203/01.PDR.0000072518.98189.A0 10.1001/archpediatrics.2011.43 10.1002/ana.23647 10.1111/j.1651-2227.2007.00364.x 10.1016/S1388-2457(00)00517-4 10.1016/j.jpeds.2017.03.065 10.1055/s-0035-1563712 10.1542/peds.2006-2839 10.1136/archdischild-2014-306191 10.1016/j.ejpn.2014.02.003 10.1371/journal.pone.0087874 10.1016/S0022-3476(81)80555-0 10.1016/j.pediatrneurol.2004.04.011 10.1038/pr.2013.206 10.1542/peds.2016-0659 10.1055/s-2002-36737 10.1016/j.pediatrneurol.2006.06.007 10.1001/archneur.1976.00500100030012 10.1016/S0022-3476(89)80132-5 10.3174/ajnr.A1318 10.1016/j.ejpn.2015.01.005 10.1136/adc.2009.160283 10.1148/radiol.11110213 10.1055/s-2007-986686 10.1371/journal.pmed.1000097 10.1016/j.jpeds.2010.03.030 10.3389/fneur.2015.00264 10.1080/00016340801996622 |
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| Keywords | Neurodevelopmental outcome Hypoxic ischaemic encephalopathy (HIE) Therapeutic hypothermia (TH) |
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| References | Wyatt, Gluckman, Liu, Azzopardi, Ballard, Edwards (bb0075) 2007 Roberts, Anderson, Doyle (bb0170) 2010; 95 Lee, Kozuki, Blencowe, Vos, Bahalim, Darmstadt (bb0005) 2013; 74 Polat, Simsek, Tansug, Sezer, Ozkol, Baspinar (bb0135) 2013; 17 (bb0040) 2014 (bb0050) 2016 Volpe (bb0190) 2012; 72 Robertson, Finer, Grace (bb0090) 1989; 114 Alderliesten, de Vries, Benders, Koopman, Groenendaal (bb0130) 2011; 261 Marlow (bb0175) 2015; 100 Nelson (bb0185) 2007; 96 Walsh, Neil, Morey, Yang, Silvera, Inder (bb0025) 2017; 187 Barnett, Mercuri, Rutherford, Haataja, Frisone, Henderson (bb0095) 2002; 33 van Schie, Schijns, Becher, Barkhof, van Weissenbruch, Vermeulen (bb0115) 2015; 19 Nagdyman, Grimmer, Scholz, Muller, Obladen (bb0110) 2003; 54 Sarnat, Sarnat (bb0010) 1976; 33 Pressler, Morton, Binnie, Rennie (bb0180) 2001; 112 Lindstrom, Hallberg, Blennow, Wolff, Fernell, Westgren (bb0165) 2008; 87 Liauw, van Wezel-Meijler, Veen, van Buchem, van der Grond (bb0120) 2009; 30 CONSORT (bb0060) 2010 Finer, Robertson, Richards, Pinnell, Peters (bb0045) 1981; 98 Lally, Price, Pauliah, Bainbridge, Kurien, Sivasamy (bb0155) 2014 van Kooij, van Handel, Nievelstein, Groenendaal, Jongmans, de Vries (bb0020) 2010; 157 Higgins (bb0030) 2011 Jacobs, Morley, Inder, Stewart, Smith, McNamara (bb0070) 2011; 165 Gardiner, Wagh, McMichael, Hakeem, Rao (bb0140) 2014; 18 Looney, Ahearne, Boylan, Murray (bb0145) 2015; 6 Murray, O'Connor, Anthony Ryan, Korotchikova, Boylan (bb0015) 2016; 138 Tekgul, Yalaz, Kutukculer, Ozbek, Kose, Akisu (bb0105) 2004; 31 Gagne-Loranger, Sheppard, Ali, Saint-Martin, Wintermark (bb0160) 2016; 33 Moher, Liberati, Tetzlaff, Altman, The (bb0055) 2009; 6 Zhou, Cheng, Shao, Liu, Shan, Zhuang (bb0080) 2010; 157 El-Ayouty, Abdel-Hady, El-Mogy, Zaghlol, El-Beltagy, Aly (bb0125) 2007; 24 Cochrane Neonatal Review Group (bb0035) Belet, Belet, Incesu, Uysal, Ozinal, Keskin (bb0150) 2004; 31 Battin, Anne Dezoete, Gunn, Gluckman, Gunn (bb0065) 2001; 107 Shany, Goldstein, Khvatskin, Friger, Heiman, Goldstein (bb0100) 2006; 35 Jacobs, Berg, Hunt, Tarnow-Mordi, Inder, Davis (bb0195) 2013; 1 Diviney, Pinnamaneni, Murphy, Lynch, Rushe, Madigan (bb0085) 2015; 108 Sarnat (10.1016/j.earlhumdev.2018.02.007_bb0010) 1976; 33 Barnett (10.1016/j.earlhumdev.2018.02.007_bb0095) 2002; 33 Pressler (10.1016/j.earlhumdev.2018.02.007_bb0180) 2001; 112 Jacobs (10.1016/j.earlhumdev.2018.02.007_bb0195) 2013; 1 (10.1016/j.earlhumdev.2018.02.007_bb0040) 2014 (10.1016/j.earlhumdev.2018.02.007_bb0050) 2016 Jacobs (10.1016/j.earlhumdev.2018.02.007_bb0070) 2011; 165 Volpe (10.1016/j.earlhumdev.2018.02.007_bb0190) 2012; 72 Wyatt (10.1016/j.earlhumdev.2018.02.007_bb0075) 2007 Liauw (10.1016/j.earlhumdev.2018.02.007_bb0120) 2009; 30 Belet (10.1016/j.earlhumdev.2018.02.007_bb0150) 2004; 31 Looney (10.1016/j.earlhumdev.2018.02.007_bb0145) 2015; 6 Alderliesten (10.1016/j.earlhumdev.2018.02.007_bb0130) 2011; 261 Roberts (10.1016/j.earlhumdev.2018.02.007_bb0170) 2010; 95 Battin (10.1016/j.earlhumdev.2018.02.007_bb0065) 2001; 107 CONSORT (10.1016/j.earlhumdev.2018.02.007_bb0060) 2010 Cochrane Neonatal Review Group (10.1016/j.earlhumdev.2018.02.007_bb0035) Tekgul (10.1016/j.earlhumdev.2018.02.007_bb0105) 2004; 31 Lindstrom (10.1016/j.earlhumdev.2018.02.007_bb0165) 2008; 87 Zhou (10.1016/j.earlhumdev.2018.02.007_bb0080) 2010; 157 van Kooij (10.1016/j.earlhumdev.2018.02.007_bb0020) 2010; 157 Finer (10.1016/j.earlhumdev.2018.02.007_bb0045) 1981; 98 van Schie (10.1016/j.earlhumdev.2018.02.007_bb0115) 2015; 19 Walsh (10.1016/j.earlhumdev.2018.02.007_bb0025) 2017; 187 Nelson (10.1016/j.earlhumdev.2018.02.007_bb0185) 2007; 96 Robertson (10.1016/j.earlhumdev.2018.02.007_bb0090) 1989; 114 Gardiner (10.1016/j.earlhumdev.2018.02.007_bb0140) 2014; 18 El-Ayouty (10.1016/j.earlhumdev.2018.02.007_bb0125) 2007; 24 Shany (10.1016/j.earlhumdev.2018.02.007_bb0100) 2006; 35 Gagne-Loranger (10.1016/j.earlhumdev.2018.02.007_bb0160) 2016; 33 Marlow (10.1016/j.earlhumdev.2018.02.007_bb0175) 2015; 100 Higgins (10.1016/j.earlhumdev.2018.02.007_bb0030) 2011 Murray (10.1016/j.earlhumdev.2018.02.007_bb0015) 2016; 138 Moher (10.1016/j.earlhumdev.2018.02.007_bb0055) 2009; 6 Polat (10.1016/j.earlhumdev.2018.02.007_bb0135) 2013; 17 Nagdyman (10.1016/j.earlhumdev.2018.02.007_bb0110) 2003; 54 Diviney (10.1016/j.earlhumdev.2018.02.007_bb0085) 2015; 108 Lee (10.1016/j.earlhumdev.2018.02.007_bb0005) 2013; 74 Lally (10.1016/j.earlhumdev.2018.02.007_bb0155) 2014 |
| References_xml | – year: 2016 ident: bb0050 publication-title: ENDNOTE™ [Internet] – volume: 261 start-page: 235 year: 2011 end-page: 242 ident: bb0130 article-title: MR imaging and outcome of term neonates with perinatal asphyxia: value of diffusion-weighted MR imaging and 1H MR spectroscopy publication-title: Radiology – volume: 108 start-page: 106 year: 2015 end-page: 109 ident: bb0085 article-title: Neurodevelopmental outcome at seven years in term, acidotic newborns publication-title: Ir. Med. J. – volume: 33 start-page: 696 year: 1976 end-page: 705 ident: bb0010 article-title: Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study publication-title: Arch. Neurol. – year: 2014 ident: bb0040 publication-title: Review Manager (RevMan) – volume: 107 start-page: 480 year: 2001 end-page: 484 ident: bb0065 article-title: Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia publication-title: Pediatrics – volume: 31 start-page: 267 year: 2004 end-page: 274 ident: bb0150 article-title: Hypoxic-ischemic encephalopathy: correlation of serial MRI and outcome publication-title: Pediatr. Neurol. – year: 2011 ident: bb0030 article-title: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [Updated March 2011] – volume: 35 start-page: 335 year: 2006 end-page: 342 ident: bb0100 article-title: Predictive value of amplitude-integrated electroencephalography pattern and voltage in asphyxiated term infants publication-title: Pediatr. Neurol. – volume: 112 start-page: 21 year: 2001 end-page: 27 ident: bb0180 article-title: Early serial EEG in hypoxic ischaemic encephalopathy publication-title: Clin. Neurophysiol. – volume: 19 start-page: 354 year: 2015 end-page: 359 ident: bb0115 article-title: Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy publication-title: Eur. J. Paediatr. Neurol. – volume: 18 start-page: 391 year: 2014 end-page: 398 ident: bb0140 article-title: Outcomes of hypoxic ischaemic encephalopathy treated with therapeutic hypothermia using cool gel packs - experience from Western Australia publication-title: Eur. J. Paediatr. Neurol. – volume: 87 start-page: 503 year: 2008 end-page: 509 ident: bb0165 article-title: Moderate neonatal encephalopathy: pre- and perinatal risk factors and long-term outcome publication-title: Acta Obstet. Gynecol. Scand. – year: 2010 ident: bb0060 article-title: CONSORT Guidelines – volume: 17 start-page: 288 year: 2013 end-page: 293 ident: bb0135 article-title: Prediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy publication-title: Eur. J. Paediatr. Neurol. – volume: 30 start-page: 264 year: 2009 end-page: 270 ident: bb0120 article-title: Do apparent diffusion coefficient measurements predict outcome in children with neonatal hypoxic-ischemic encephalopathy? publication-title: AJNR Am. J. Neuroradiol. – ident: bb0035 – volume: 6 start-page: 264 year: 2015 ident: bb0145 article-title: Glial fibrillary acidic protein is not an early marker of injury in perinatal asphyxia and hypoxic-ischemic encephalopathy publication-title: Front. Neurol. – volume: 187 start-page: 26 year: 2017 end-page: 33 ident: bb0025 article-title: The frequency and severity of magnetic resonance imaging abnormalities in infants with mild neonatal encephalopathy publication-title: J. Pediatr. – volume: 96 start-page: 1113 year: 2007 end-page: 1114 ident: bb0185 article-title: Is it HIE? And why that matters publication-title: Acta Paediatr. – volume: 24 start-page: 467 year: 2007 end-page: 473 ident: bb0125 article-title: Relationship between electroencephalography and magnetic resonance imaging findings after hypoxic-ischemic encephalopathy at term publication-title: Am. J. Perinatol. – volume: 138 year: 2016 ident: bb0015 article-title: Early EEG grade and outcome at 5 years after mild neonatal hypoxic ischemic encephalopathy publication-title: Pediatrics – volume: 72 start-page: 156 year: 2012 end-page: 166 ident: bb0190 article-title: Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy publication-title: Ann. Neurol. – volume: 31 start-page: 326 year: 2004 end-page: 332 ident: bb0105 article-title: Value of biochemical markers for outcome in term infants with asphyxia publication-title: Pediatr. Neurol. – volume: 33 start-page: 242 year: 2002 end-page: 248 ident: bb0095 article-title: Neurological and perceptual-motor outcome at 5–6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI publication-title: Neuropediatrics – volume: 1 start-page: CD003311 year: 2013 ident: bb0195 article-title: Cooling for newborns with hypoxic ischaemic encephalopathy publication-title: Cochrane Database Syst. Rev. – volume: 95 start-page: 786 year: 2010 end-page: 790 ident: bb0170 article-title: The stability of the diagnosis of developmental disability between ages 2 and 8 in a geographic cohort of very preterm children born in 1997 publication-title: Arch. Dis. Child. – volume: 157 year: 2010 ident: bb0080 article-title: Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China publication-title: J. Pediatr. – volume: 157 year: 2010 ident: bb0020 article-title: Serial MRI and neurodevelopmental outcome in 9- to 10-year-old children with neonatal encephalopathy publication-title: J. Pediatr. – start-page: e87874 year: 2014 ident: bb0155 article-title: Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome publication-title: PLoS One – start-page: 912 year: 2007 end-page: 921 ident: bb0075 article-title: Determinants of outcomes after head cooling for neonatal encephalopathy publication-title: Pediatrics – volume: 74 start-page: 50 year: 2013 end-page: 72 ident: bb0005 article-title: Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990 publication-title: Pediatr. Res. – volume: 98 start-page: 112 year: 1981 end-page: 117 ident: bb0045 article-title: Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome publication-title: J. Pediatr. – volume: 6 year: 2009 ident: bb0055 article-title: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement publication-title: PLoS Med. – volume: 165 start-page: 692 year: 2011 end-page: 700 ident: bb0070 article-title: Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial publication-title: Arch. Pediatr. Adolesc. Med. – volume: 33 start-page: 195 year: 2016 end-page: 202 ident: bb0160 article-title: Newborns referred for therapeutic hypothermia: association between initial degree of encephalopathy and severity of brain injury (what about the newborns with mild encephalopathy on admission?) publication-title: Am. J. Perinatol. – volume: 114 start-page: 753 year: 1989 end-page: 760 ident: bb0090 article-title: School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term publication-title: J. Pediatr. – volume: 54 start-page: 270 year: 2003 end-page: 275 ident: bb0110 article-title: Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia publication-title: Pediatr. Res. – volume: 100 start-page: F82 year: 2015 end-page: 4 ident: bb0175 article-title: Is survival and neurodevelopmental impairment at 2 years of age the gold standard outcome for neonatal studies? publication-title: Arch. Dis. Child. Fetal Neonatal Ed. – year: 2014 ident: 10.1016/j.earlhumdev.2018.02.007_bb0040 – volume: 157 year: 2010 ident: 10.1016/j.earlhumdev.2018.02.007_bb0020 article-title: Serial MRI and neurodevelopmental outcome in 9- to 10-year-old children with neonatal encephalopathy publication-title: J. Pediatr. doi: 10.1016/j.jpeds.2010.02.016 – volume: 17 start-page: 288 year: 2013 ident: 10.1016/j.earlhumdev.2018.02.007_bb0135 article-title: Prediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy publication-title: Eur. J. Paediatr. Neurol. doi: 10.1016/j.ejpn.2012.11.004 – volume: 107 start-page: 480 year: 2001 ident: 10.1016/j.earlhumdev.2018.02.007_bb0065 article-title: Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia publication-title: Pediatrics doi: 10.1542/peds.107.3.480 – volume: 31 start-page: 326 year: 2004 ident: 10.1016/j.earlhumdev.2018.02.007_bb0105 article-title: Value of biochemical markers for outcome in term infants with asphyxia publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2004.05.004 – volume: 54 start-page: 270 year: 2003 ident: 10.1016/j.earlhumdev.2018.02.007_bb0110 article-title: Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia publication-title: Pediatr. Res. doi: 10.1203/01.PDR.0000072518.98189.A0 – year: 2011 ident: 10.1016/j.earlhumdev.2018.02.007_bb0030 – volume: 165 start-page: 692 year: 2011 ident: 10.1016/j.earlhumdev.2018.02.007_bb0070 article-title: Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial publication-title: Arch. Pediatr. Adolesc. Med. doi: 10.1001/archpediatrics.2011.43 – volume: 72 start-page: 156 year: 2012 ident: 10.1016/j.earlhumdev.2018.02.007_bb0190 article-title: Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy publication-title: Ann. Neurol. doi: 10.1002/ana.23647 – volume: 96 start-page: 1113 year: 2007 ident: 10.1016/j.earlhumdev.2018.02.007_bb0185 article-title: Is it HIE? And why that matters publication-title: Acta Paediatr. doi: 10.1111/j.1651-2227.2007.00364.x – volume: 108 start-page: 106 year: 2015 ident: 10.1016/j.earlhumdev.2018.02.007_bb0085 article-title: Neurodevelopmental outcome at seven years in term, acidotic newborns publication-title: Ir. Med. J. – volume: 112 start-page: 21 year: 2001 ident: 10.1016/j.earlhumdev.2018.02.007_bb0180 article-title: Early serial EEG in hypoxic ischaemic encephalopathy publication-title: Clin. Neurophysiol. doi: 10.1016/S1388-2457(00)00517-4 – volume: 187 start-page: 26 year: 2017 ident: 10.1016/j.earlhumdev.2018.02.007_bb0025 article-title: The frequency and severity of magnetic resonance imaging abnormalities in infants with mild neonatal encephalopathy publication-title: J. Pediatr. doi: 10.1016/j.jpeds.2017.03.065 – volume: 33 start-page: 195 year: 2016 ident: 10.1016/j.earlhumdev.2018.02.007_bb0160 article-title: Newborns referred for therapeutic hypothermia: association between initial degree of encephalopathy and severity of brain injury (what about the newborns with mild encephalopathy on admission?) publication-title: Am. J. Perinatol. doi: 10.1055/s-0035-1563712 – start-page: 912 year: 2007 ident: 10.1016/j.earlhumdev.2018.02.007_bb0075 article-title: Determinants of outcomes after head cooling for neonatal encephalopathy publication-title: Pediatrics doi: 10.1542/peds.2006-2839 – volume: 100 start-page: F82 year: 2015 ident: 10.1016/j.earlhumdev.2018.02.007_bb0175 article-title: Is survival and neurodevelopmental impairment at 2 years of age the gold standard outcome for neonatal studies? publication-title: Arch. Dis. Child. Fetal Neonatal Ed. doi: 10.1136/archdischild-2014-306191 – volume: 18 start-page: 391 year: 2014 ident: 10.1016/j.earlhumdev.2018.02.007_bb0140 article-title: Outcomes of hypoxic ischaemic encephalopathy treated with therapeutic hypothermia using cool gel packs - experience from Western Australia publication-title: Eur. J. Paediatr. Neurol. doi: 10.1016/j.ejpn.2014.02.003 – start-page: e87874 year: 2014 ident: 10.1016/j.earlhumdev.2018.02.007_bb0155 article-title: Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome publication-title: PLoS One doi: 10.1371/journal.pone.0087874 – volume: 98 start-page: 112 year: 1981 ident: 10.1016/j.earlhumdev.2018.02.007_bb0045 article-title: Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome publication-title: J. Pediatr. doi: 10.1016/S0022-3476(81)80555-0 – volume: 31 start-page: 267 year: 2004 ident: 10.1016/j.earlhumdev.2018.02.007_bb0150 article-title: Hypoxic-ischemic encephalopathy: correlation of serial MRI and outcome publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2004.04.011 – volume: 74 start-page: 50 issue: Suppl. 1 year: 2013 ident: 10.1016/j.earlhumdev.2018.02.007_bb0005 article-title: Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990 publication-title: Pediatr. Res. doi: 10.1038/pr.2013.206 – volume: 138 issue: 4 year: 2016 ident: 10.1016/j.earlhumdev.2018.02.007_bb0015 article-title: Early EEG grade and outcome at 5 years after mild neonatal hypoxic ischemic encephalopathy publication-title: Pediatrics doi: 10.1542/peds.2016-0659 – volume: 33 start-page: 242 year: 2002 ident: 10.1016/j.earlhumdev.2018.02.007_bb0095 article-title: Neurological and perceptual-motor outcome at 5–6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI publication-title: Neuropediatrics doi: 10.1055/s-2002-36737 – volume: 35 start-page: 335 year: 2006 ident: 10.1016/j.earlhumdev.2018.02.007_bb0100 article-title: Predictive value of amplitude-integrated electroencephalography pattern and voltage in asphyxiated term infants publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2006.06.007 – volume: 33 start-page: 696 year: 1976 ident: 10.1016/j.earlhumdev.2018.02.007_bb0010 article-title: Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study publication-title: Arch. Neurol. doi: 10.1001/archneur.1976.00500100030012 – ident: 10.1016/j.earlhumdev.2018.02.007_bb0035 – volume: 114 start-page: 753 year: 1989 ident: 10.1016/j.earlhumdev.2018.02.007_bb0090 article-title: School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term publication-title: J. Pediatr. doi: 10.1016/S0022-3476(89)80132-5 – year: 2010 ident: 10.1016/j.earlhumdev.2018.02.007_bb0060 – volume: 30 start-page: 264 year: 2009 ident: 10.1016/j.earlhumdev.2018.02.007_bb0120 article-title: Do apparent diffusion coefficient measurements predict outcome in children with neonatal hypoxic-ischemic encephalopathy? publication-title: AJNR Am. J. Neuroradiol. doi: 10.3174/ajnr.A1318 – volume: 1 start-page: CD003311 year: 2013 ident: 10.1016/j.earlhumdev.2018.02.007_bb0195 article-title: Cooling for newborns with hypoxic ischaemic encephalopathy publication-title: Cochrane Database Syst. Rev. – volume: 19 start-page: 354 year: 2015 ident: 10.1016/j.earlhumdev.2018.02.007_bb0115 article-title: Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy publication-title: Eur. J. Paediatr. Neurol. doi: 10.1016/j.ejpn.2015.01.005 – volume: 95 start-page: 786 year: 2010 ident: 10.1016/j.earlhumdev.2018.02.007_bb0170 article-title: The stability of the diagnosis of developmental disability between ages 2 and 8 in a geographic cohort of very preterm children born in 1997 publication-title: Arch. Dis. Child. doi: 10.1136/adc.2009.160283 – volume: 261 start-page: 235 year: 2011 ident: 10.1016/j.earlhumdev.2018.02.007_bb0130 article-title: MR imaging and outcome of term neonates with perinatal asphyxia: value of diffusion-weighted MR imaging and 1H MR spectroscopy publication-title: Radiology doi: 10.1148/radiol.11110213 – volume: 24 start-page: 467 year: 2007 ident: 10.1016/j.earlhumdev.2018.02.007_bb0125 article-title: Relationship between electroencephalography and magnetic resonance imaging findings after hypoxic-ischemic encephalopathy at term publication-title: Am. J. Perinatol. doi: 10.1055/s-2007-986686 – year: 2016 ident: 10.1016/j.earlhumdev.2018.02.007_bb0050 – volume: 6 year: 2009 ident: 10.1016/j.earlhumdev.2018.02.007_bb0055 article-title: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement publication-title: PLoS Med. doi: 10.1371/journal.pmed.1000097 – volume: 157 year: 2010 ident: 10.1016/j.earlhumdev.2018.02.007_bb0080 article-title: Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China publication-title: J. Pediatr. doi: 10.1016/j.jpeds.2010.03.030 – volume: 6 start-page: 264 year: 2015 ident: 10.1016/j.earlhumdev.2018.02.007_bb0145 article-title: Glial fibrillary acidic protein is not an early marker of injury in perinatal asphyxia and hypoxic-ischemic encephalopathy publication-title: Front. Neurol. doi: 10.3389/fneur.2015.00264 – volume: 87 start-page: 503 year: 2008 ident: 10.1016/j.earlhumdev.2018.02.007_bb0165 article-title: Moderate neonatal encephalopathy: pre- and perinatal risk factors and long-term outcome publication-title: Acta Obstet. Gynecol. Scand. doi: 10.1080/00016340801996622 |
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| Snippet | Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE,... |
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| SubjectTerms | Brain Diseases - physiopathology Brain Diseases - therapy Developmental Disabilities - etiology Humans Hypothermia, Induced - methods Hypoxia-Ischemia, Brain - physiopathology Hypoxia-Ischemia, Brain - therapy Hypoxic ischaemic encephalopathy (HIE) Infant, Newborn Infant, Newborn, Diseases - physiopathology Infant, Newborn, Diseases - therapy Neurodevelopmental outcome Therapeutic hypothermia (TH) Treatment Outcome |
| Title | Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - A systematic review |
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