Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection - Lang, Bin; Wang, Meiting; Zhang, Zining; Fu, Yajing; Han, Xiaoxu; Hu, Qinghai; Ding, Haibo; Shang, Hong; Jiang, Yongjun (Journal of translational medicine, 2023)
Keywords: Antibodies; CD47; CD47 Antigen; Cell activation; Cell differentiation; Enzyme-linked immunosorbent assay; Flow cytometry; HIV; HIV infection; HIV Infections; Human immunodeficiency virus; Humans; IFN-γ; Infections; Interferon-gamma - metabolism; JAK–STAT3; Janus kinase; Janus Kinases - metabolism; Killer Cells, Natural - metabolism; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Ligands; Lymphocytes; Natural killer cells; NK cells; Peripheral blood mononuclear cells; Phosphorylation; Plasma; Proteins; Receptor mechanisms; Signal regulatory protein-α; Signal transduction; Software; Stat3 protein; STAT3 Transcription Factor - metabolism; Thrombospondin; TLR7 protein; Toll-Like Receptor 7; Toll-like receptors; TSP1; γ-Interferon; China; JAK–STAT3; IFN-γ; NK cells; CD47; HIV infection; TSP1