Microglial activation induced by LPS mediates excitation of neurons in the hypothalamic paraventricular nucleus projecting to the rostral ventrolateral medulla

• Published in: BMB reports Vol. 54; no. 12; pp. 620 - 625
• Main Authors: Han, Tae Hee, Lee, Heow Won, Kang, Eun A, Song, Min Seok, Lee, So Yeong, Ryu, Pan Dong
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society for Biochemistry and Molecular Biology 31.12.2021; 생화학분자생물학회
• Subjects: Animals; Lipopolysaccharides - pharmacology; Microglia; Neural Pathways - physiology; Neurons; Paraventricular Hypothalamic Nucleus - physiology; Rats; Rats, Sprague-Dawley; 화학

Microglia are known to be activated in the hypothalamic paraventricular nucleus (PVN) of rats with cardiovascular diseases. However, the exact role of microglial activation in the plasticity of presympathetic PVN neurons associated with the modulation of sympathetic outflow remains poorly investigat...