Top–down modulation of prepulse inhibition of the startle reflex in humans and rats

• Published in: Neuroscience and biobehavioral reviews Vol. 33; no. 8; pp. 1157 - 1167
• Main Authors: Li, Liang, Du, Yi, Li, Nanxin, Wu, Xihong, Wu, Yanhong
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2009; Elsevier
• Subjects: Acoustic Stimulation; Adult and adolescent clinical studies; Amygdala; Animal model; Animals; Attention - physiology; Attentional modulation; Auditory fear conditioning; Behavioral psychophysiology; Biological and medical sciences; Brain - physiology; Cognition - physiology; Conditioning, Classical - physiology; Fundamental and applied biological sciences. Psychology; Humans; Inferior colliculus; Inhibition (Psychology); Medical sciences; Neural Inhibition - physiology; Prepulse inhibition; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Psychoses; Rats; Reaction Time - physiology; Reflex, Startle - physiology; Schizophrenia; Sensory Gating - physiology; Attentional modulation; Animal model; Amygdala; Inferior colliculus; Auditory fear conditioning; Schizophrenia; Prepulse inhibition; Affect affectivity; Rat; Central nervous system; Review; Startle reflex; Encephalon; Psychosis; Conditioning; Amygdaloid nucleus; Human; Rodentia; Attention; Basal ganglion; Emotion emotionality; Fear; Vertebrata; Hearing; Mammalia; Colliculus inferior; Animal; Auditory pathway

Prepulse inhibition (PPI) is the attenuation of the startle reflex when the sudden intense startling stimulus is shortly preceded by a weaker, non-startling sensory stimulus (prepulse). PPI reflects a protective function of reducing disruptive influences to the processing of prepulse signals and is...