Emerging Roles of TRIM56 in Antiviral Innate Immunity

• Published in: Viruses Vol. 17; no. 1; p. 72
• Main Authors: Wang, Dang, Li, Kui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2025; MDPI
• Subjects: Analysis; Animals; Antiviral activity; Antiviral agents; Antiviral drugs; Autophagy; Autophagy (Cytology); Binding proteins; cGAS; Control; Cytokines; Dosage and administration; Double-stranded RNA; Enzymes; Genes; Host-Pathogen Interactions - immunology; Humans; Identification and classification; Immunity, Innate; Infections; Innate immunity; Kinases; Proteins; restriction factor; Review; RNA viruses; RNA Viruses - immunology; RNA-binding protein; Signal Transduction; TLR3; TLR3 protein; Toll-like receptors; Transcription factors; TRIF; TRIM56; Tripartite Motif Proteins - genetics; Tripartite Motif Proteins - immunology; Tripartite Motif Proteins - metabolism; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - immunology; Ubiquitin-Protein Ligases - metabolism; Viral infections; virus; Virus Diseases - immunology; Virus Diseases - virology; Viruses; Viruses - immunology; United States; cGAS; restriction factor; STING; TRIF; virus; TLR3; TRIM56

The tripartite-motif protein 56 (TRIM56) is a RING-type E3 ubiquitin ligase whose functions were recently beginning to be unveiled. While the physiological role(s) of TRIM56 remains unclear, emerging evidence suggests this protein participates in host innate defense mechanisms that guard against vir...