Effect of recombinant human nerve growth factor treatment on corneal nerve regeneration in patients with neurotrophic keratopathy

• Published in: Frontiers in neuroscience Vol. 17; p. 1210179
• Main Authors: Balbuena-Pareja, Ana, Bogen, Chloe S., Cox, Stephanie M., Hamrah, Pedram
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 30.10.2023; Frontiers Media S.A
• Subjects: Acuity; cenegermin; Confocal microscopy; Cornea; corneal nerves; Eye diseases; Growth factors; Microscopy; Nerve growth factor; Nerves; Neuroscience; neurotrophic keratitis; neurotrophic keratopathy; Patients; recombinant human nerve growth factor; Regeneration; Sensation; Ulcers; Visual acuity; England; United Kingdom > UK; United States > US; Massachusetts; Germany; recombinant human nerve growth factor; cenegermin; neurotrophic keratopathy; corneal nerves; neurotrophic keratitis

Neurotrophic Keratopathy (NK) is a neurodegenerative corneal disease that results in diminished corneal sensation. Previous studies have found that Cenegermin 0.002%, a recombinant human nerve growth factor (rhNGF), improves corneal epithelial healing in stage 2 and 3 NK patients. However, rhNGF eff...