Molecular differences in brain regional vulnerability to aging between males and females

• Published in: Frontiers in aging neuroscience Vol. 15; p. 1153251
• Main Authors: Zhou, Xianxiao, Cao, Jiqing, Zhu, Li, Farrell, Kurt, Wang, Minghui, Guo, Lei, Yang, Jialiang, McKenzie, Andrew, Crary, John F, Cai, Dongming, Tu, Zhidong, Zhang, Bin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 22.05.2023; Frontiers Media S.A
• Subjects: Age; Aging; Alzheimer's disease; Brain; brain aging; Cerebellum; Cognitive ability; Consortia; Cortex (cingulate); Cortex (frontal); Epigenetics; Females; Gender differences; gene co-expression network; Gene expression; Hippocampus; Hypothalamus; Immune response; key regulators; Males; Molecular modelling; Morphogenesis; Myelin proteolipid protein; Myelination; Neurodegenerative diseases; Neurogenesis; Neuropathology; Neuroscience; Oligodendrocyte-myelin glycoprotein; Sex differences; Transcriptomics; brain aging; key regulators; Alzheimer’s disease; gender differences; gene co-expression network

Aging-related cognitive decline is associated with brain structural changes and synaptic loss. However, the molecular mechanisms of cognitive decline during normal aging remain elusive. Using the GTEx transcriptomic data from 13 brain regions, we identified aging-associated molecular alterations and...