Single-Nucleotide Polymorphisms in Human NPC1 Influence Filovirus Entry Into Cells

• Published in: The Journal of infectious diseases Vol. 218; no. suppl_5; pp. S397 - S402
• Main Authors: Kondoh, Tatsunari, Letko, Michael, Munster, Vincent J, Manzoor, Rashid, Maruyama, Junki, Furuyama, Wakako, Miyamoto, Hiroko, Shigeno, Asako, Fujikura, Daisuke, Takadate, Yoshihiro, Yoshida, Reiko, Igarashi, Manabu, Feldmann, Heinz, Marzi, Andrea, Takada, Ayato
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 22.11.2018
• Subjects: Animals; Carrier Proteins - genetics; Cell Line; Chlorocebus aethiops; Ebolavirus - pathogenicity; HEK293 Cells; Hemorrhagic Fever, Ebola - genetics; Hemorrhagic Fever, Ebola - virology; Humans; Membrane Glycoproteins - genetics; Polymorphism, Single Nucleotide - genetics; Receptors, Virus - metabolism; Supplement; Vero Cells; Viral Envelope Proteins - metabolism; Virus Internalization

Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)–mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. It is known that proteolytically digested Ebola virus (EBOV) GP interacts with 2 protrudin...