Neutrophil Elastase-Mediated Lung Disease

• Published in: Chronic obstructive pulmonary disease Vol. 10; no. S1; pp. 60 - 63
• Main Authors: Sandhaus, Robert A., Turino, Gerard
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.03.2013; Taylor & Francis
• Subjects: alpha 1-Antitrypsin - therapeutic use; alpha 1-Antitrypsin Deficiency - drug therapy; alpha 1-Antitrypsin Deficiency - enzymology; alpha-1 antitrypsin deficiency; emphysema; Humans; Leukocyte Elastase - metabolism; neutrophil elastase; Pulmonary Emphysema - enzymology; Pulmonary Emphysema - etiology; Serine Proteinase Inhibitors - therapeutic use

AbstractElastases of both the neutrophil and macrophage have been implicated in lung disease initiation and progression. Although it is unlikely that these proteases evolved for the purpose of injuring lung tissue, the elastin-rich connective tissue framework of the lungs appears to be particularly...