A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3‐kinase/v‐akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma

• Published in: BJU international Vol. 110; no. 11c; pp. E1237 - E1248
• Main Authors: Korkolopoulou, Penelope, Levidou, Georgia, Trigka, Eleni‐Andriana, Prekete, Niki, Karlou, Maria, Thymara, Irene, Sakellariou, Stratigoula, Fragkou, Paraskevi, Isaiadis, Dimitrios, Pavlopoulos, Petros, Patsouris, Efstratios, Saetta, Angelica A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2012; Wiley Subscription Services, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; 4E‐BP1; Adult; Aged; Aged, 80 and over; AKT; AKT protein; AKT1; AKT1 protein; bladder cancer; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Chemotherapy; Class I Phosphatidylinositol 3-Kinases; DNA, Neoplasm - genetics; Extracellular signal-regulated kinase; Female; Fibroblast growth factor receptor 3; Fibroblast growth factor receptors; Follow-Up Studies; Humans; Immunohistochemistry; Initiation factors; Kinases; Male; Middle Aged; mTOR; Mutation; Oncogenes; p70S6K; p85aPI3K; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; phosphoinositides; PIK3CA; Polymerase Chain Reaction; Prognosis; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Regulatory subunits; Retrospective Studies; Signal Transduction; Studies; Survival; Survival analysis; thymoma; TOR protein; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tumorigenesis; UCS; Urinary bladder; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; urothelial carcinoma; urothelium

What's known on the subject? and What does the study add? A few published studies investigating single or various PI3K/AKT/mTOR signalling components have produced inconsistent results. Moreover, PI3K regulatory subunit p85a and activated p70S6K expression levels have not been previously examin...