Transduction signals induced in rat brain cortex astrocytes by the HIV-1 gp120 glycoprotein

• Published in: FEBS letters Vol. 384; no. 2; pp. 135 - 137
• Main Authors: Codazzi, F., Racchetti, G., Grohovaz, F., Meldolesi, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.04.1996
• Subjects: [Ca 2+] i; [Ca2+]i; Animals; Astrocyte; Astrocytes - drug effects; Astrocytes - physiology; Biological Transport - drug effects; Calcium - metabolism; Cells, Cultured; Cerebral Cortex - cytology; Chelating Agents - pharmacology; Egtazic Acid - analogs & derivatives; Egtazic Acid - pharmacology; gp120; HIV Envelope Protein gp120 - pharmacology; HIV neurotoxicity; HIV-1 - physiology; human immunodeficiency virus 1; Nerve Tissue Proteins - metabolism; Phosphorylation; Protein Processing, Post-Translational - drug effects; Rats; Signal Transduction - drug effects; Tyrosine phosphorylation; gp120; [Ca 2+] i; HIV neurotoxicity; Astrocyte; Tyrosine phosphorylation

Cultures of rat brain cortex astrocytes were exposed to 10 −10−10 −9 M of the HIV-1 envelope glycoprotein, gp120. No specific binding was revealed by the iodinated protein, suggesting expression of only a few sites onto the cells. In contrast, two transduction signals were rapidly induced by gp120:...