Cellular sources of IL-17 in psoriasis: a paradigm shift?

• Published in: Experimental dermatology Vol. 23; no. 11; pp. 799 - 803
• Main Authors: Keijsers, Romy R. M. C., Joosten, Irma, van Erp, Piet E. J, Koenen, Hans J. P. M., van de Kerkhof, Peter. C. M.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.11.2014
• Subjects: Animals; Cell Movement; Cell Proliferation; Gene Expression Regulation; Humans; IL-17; Immunity, Innate; Inflammation - immunology; Interleukin-17 - immunology; Keratinocytes - cytology; mast cells; Mast Cells - immunology; Mice; neutrophils; Neutrophils - immunology; Psoriasis - immunology; Receptors, Antigen, T-Cell, gamma-delta - metabolism; Skin - metabolism; T cells; T-Lymphocyte Subsets - immunology; Th17 Cells - immunology; Transcriptome; γδ T cells; γδ T cells; T cells; mast cells; neutrophils; IL-17

Psoriasis is a common chronic inflammatory skin disease that results from interplay between the immune system and the epithelium. In the light of very successful anticytokine therapies for psoriasis, the focus has been directed towards the adaptive immune system. Expression studies, genetic studies...