Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition - Taylor, Isabella C.; Hütt-Cabezas, Marianne; Brandt, William D.; Kambhampati, Madhuri; Nazarian, Javad; Chang, Howard T.; Warren, Katherine E.; Eberhart, Charles G.; Raabe, Eric H. (Journal of neuropathology and experimental neurology, 2015)
Keywords: Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Blotting, Western; Brain Stem Neoplasms - metabolism; Brain Stem Neoplasms - pathology; Fluorescent Antibody Technique; Glioma - metabolism; Glioma - pathology; Humans; Mice; Mice, Nude; N-Myc Proto-Oncogene Protein; Nuclear Proteins - metabolism; Oncogene Proteins - metabolism; Pons - metabolism; Pons - pathology; Radiation Tolerance - physiology; Xenograft Model Antitumor Assays; γ-secretase inhibitor; Pediatric brain tumor; Diffuse intrinsic pontine glioma; MRK003; HES; Radiation