In vitro degradation, biocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid)/calcium phosphate cement scaffold with unidirectional lamellar pore structure

• Published in: Journal of biomedical materials research. Part A Vol. 100A; no. 12; pp. 3239 - 3250
• Main Authors: He, Fupo, Ye, Jiandong
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2012; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Alkaline phosphatase; Animals; Biocompatibility; Biocompatible Materials - pharmacology; Biological and medical sciences; Biomedical materials; Bone Cements - pharmacology; calcium phosphate cement; Calcium phosphates; Calcium Phosphates - pharmacology; Cell culture; Cell differentiation; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell viability; Cement; Compressive Strength - drug effects; cytocompatibility; Degradability; Degradation; Femur - drug effects; Femur - pathology; Glycolic acid; Hydrogen-Ion Concentration - drug effects; In vivo methods and tests; Lactic Acid - pharmacology; Lamellar structure; Materials Testing - methods; Mechanical properties; Medical sciences; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - enzymology; Mesenchyme; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Orthopedic surgery; Osteogenesis; Osteogenesis - drug effects; PLGA; Polyglycolic Acid - pharmacology; Polylactide-co-glycolide; Porosity; Prolongation; Rabbits; Rats; scaffold; Scaffolds; Stem cell transplantation; Stem cells; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical implants; Technology. Biomaterials. Equipments; Time Factors; Tissue engineering; Tissue Scaffolds - chemistry; unidirectional lamellar pore; Biodegradation; Glycolic acid copolymer; Biological properties; Lactone copolymer; Biodegradability; Lactic acid copolymer; calcium phosphate cement; Calcium phosphate; degradation; Scaffold; In vivo; Lamellar structure; PLGA; cytocompatibility; Biocompatibility; Biomaterial; Osteogenesis; Biomedical engineering; unidirectional lamellar pore

The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic‐co‐glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC‐based scaffold was fabricated by unidirectional freeze casti...