In vitro degradation, biocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid)/calcium phosphate cement scaffold with unidirectional lamellar pore structure
The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic‐co‐glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC‐based scaffold was fabricated by unidirectional freeze casti...
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| Published in | Journal of biomedical materials research. Part A Vol. 100A; no. 12; pp. 3239 - 3250 |
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| Language | English |
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| Abstract | The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic‐co‐glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC‐based scaffold was fabricated by unidirectional freeze casting, and PLGA was used to improve the mechanical properties of the CPC‐based scaffold, which covered the surface of the pore wall as coating. The in vitro degradation results demonstrated that the PLGA/CPC scaffold had good degradability. The degradation of PLGA film on the surface of the scaffold made the CPC matrix exposed, which facilitated cell response and osteogenesis. Rat bone mesenchymal stem cells (rMSCs) were seeded on the PLGA/CPC composite scaffold. Cell viability, proliferation, and differentiation on the PLGA/CPC composite scaffold were evaluated. The results showed that viable rMSCs attached on the surface of pore wall gradually penetrated into the internal pores of the scaffold as prolongation of culture time. In addition, the rMSCs seeded on the scaffold exhibited good proliferation and growing alkaline phosphatase activity. The scaffold was implanted in the defects in distal end of femora of New Zealand white rabbits. Histological evaluation indicated that the PLGA/CPC scaffold with unidirectional lamellar pore structure had good biocompatibility and effective osteogenesis. These results suggest PLGA/CPC composite scaffold with unidirectional lamellar pore structure is a promising scaffold for bone tissue engineering. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:3239–3250, 2012. |
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| AbstractList | The aim of this study was to investigate the
in vitro
degradation, cytocompatibility, and
in vivo
osteogenesis of poly(lactic‐
co
‐glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC‐based scaffold was fabricated by unidirectional freeze casting, and PLGA was used to improve the mechanical properties of the CPC‐based scaffold, which covered the surface of the pore wall as coating. The
in vitro
degradation results demonstrated that the PLGA/CPC scaffold had good degradability. The degradation of PLGA film on the surface of the scaffold made the CPC matrix exposed, which facilitated cell response and osteogenesis. Rat bone mesenchymal stem cells (rMSCs) were seeded on the PLGA/CPC composite scaffold. Cell viability, proliferation, and differentiation on the PLGA/CPC composite scaffold were evaluated. The results showed that viable rMSCs attached on the surface of pore wall gradually penetrated into the internal pores of the scaffold as prolongation of culture time. In addition, the rMSCs seeded on the scaffold exhibited good proliferation and growing alkaline phosphatase activity. The scaffold was implanted in the defects in distal end of femora of New Zealand white rabbits. Histological evaluation indicated that the PLGA/CPC scaffold with unidirectional lamellar pore structure had good biocompatibility and effective osteogenesis. These results suggest PLGA/CPC composite scaffold with unidirectional lamellar pore structure is a promising scaffold for bone tissue engineering. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:3239–3250, 2012. The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC-based scaffold was fabricated by unidirectional freeze casting, and PLGA was used to improve the mechanical properties of the CPC-based scaffold, which covered the surface of the pore wall as coating. The in vitro degradation results demonstrated that the PLGA/CPC scaffold had good degradability. The degradation of PLGA film on the surface of the scaffold made the CPC matrix exposed, which facilitated cell response and osteogenesis. Rat bone mesenchymal stem cells (rMSCs) were seeded on the PLGA/CPC composite scaffold. Cell viability, proliferation, and differentiation on the PLGA/CPC composite scaffold were evaluated. The results showed that viable rMSCs attached on the surface of pore wall gradually penetrated into the internal pores of the scaffold as prolongation of culture time. In addition, the rMSCs seeded on the scaffold exhibited good proliferation and growing alkaline phosphatase activity. The scaffold was implanted in the defects in distal end of femora of New Zealand white rabbits. Histological evaluation indicated that the PLGA/CPC scaffold with unidirectional lamellar pore structure had good biocompatibility and effective osteogenesis. These results suggest PLGA/CPC composite scaffold with unidirectional lamellar pore structure is a promising scaffold for bone tissue engineering.The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC-based scaffold was fabricated by unidirectional freeze casting, and PLGA was used to improve the mechanical properties of the CPC-based scaffold, which covered the surface of the pore wall as coating. The in vitro degradation results demonstrated that the PLGA/CPC scaffold had good degradability. The degradation of PLGA film on the surface of the scaffold made the CPC matrix exposed, which facilitated cell response and osteogenesis. Rat bone mesenchymal stem cells (rMSCs) were seeded on the PLGA/CPC composite scaffold. Cell viability, proliferation, and differentiation on the PLGA/CPC composite scaffold were evaluated. The results showed that viable rMSCs attached on the surface of pore wall gradually penetrated into the internal pores of the scaffold as prolongation of culture time. In addition, the rMSCs seeded on the scaffold exhibited good proliferation and growing alkaline phosphatase activity. The scaffold was implanted in the defects in distal end of femora of New Zealand white rabbits. Histological evaluation indicated that the PLGA/CPC scaffold with unidirectional lamellar pore structure had good biocompatibility and effective osteogenesis. These results suggest PLGA/CPC composite scaffold with unidirectional lamellar pore structure is a promising scaffold for bone tissue engineering. The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic‐co‐glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC‐based scaffold was fabricated by unidirectional freeze casting, and PLGA was used to improve the mechanical properties of the CPC‐based scaffold, which covered the surface of the pore wall as coating. The in vitro degradation results demonstrated that the PLGA/CPC scaffold had good degradability. The degradation of PLGA film on the surface of the scaffold made the CPC matrix exposed, which facilitated cell response and osteogenesis. Rat bone mesenchymal stem cells (rMSCs) were seeded on the PLGA/CPC composite scaffold. Cell viability, proliferation, and differentiation on the PLGA/CPC composite scaffold were evaluated. The results showed that viable rMSCs attached on the surface of pore wall gradually penetrated into the internal pores of the scaffold as prolongation of culture time. In addition, the rMSCs seeded on the scaffold exhibited good proliferation and growing alkaline phosphatase activity. The scaffold was implanted in the defects in distal end of femora of New Zealand white rabbits. Histological evaluation indicated that the PLGA/CPC scaffold with unidirectional lamellar pore structure had good biocompatibility and effective osteogenesis. These results suggest PLGA/CPC composite scaffold with unidirectional lamellar pore structure is a promising scaffold for bone tissue engineering. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:3239–3250, 2012. The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid) (PLGA)/calcium phosphate cement (CPC) scaffold with unidirectional lamellar pore structure. CPC-based scaffold was fabricated by unidirectional freeze casting, and PLGA was used to improve the mechanical properties of the CPC-based scaffold, which covered the surface of the pore wall as coating. The in vitro degradation results demonstrated that the PLGA/CPC scaffold had good degradability. The degradation of PLGA film on the surface of the scaffold made the CPC matrix exposed, which facilitated cell response and osteogenesis. Rat bone mesenchymal stem cells (rMSCs) were seeded on the PLGA/CPC composite scaffold. Cell viability, proliferation, and differentiation on the PLGA/CPC composite scaffold were evaluated. The results showed that viable rMSCs attached on the surface of pore wall gradually penetrated into the internal pores of the scaffold as prolongation of culture time. In addition, the rMSCs seeded on the scaffold exhibited good proliferation and growing alkaline phosphatase activity. The scaffold was implanted in the defects in distal end of femora of New Zealand white rabbits. Histological evaluation indicated that the PLGA/CPC scaffold with unidirectional lamellar pore structure had good biocompatibility and effective osteogenesis. These results suggest PLGA/CPC composite scaffold with unidirectional lamellar pore structure is a promising scaffold for bone tissue engineering. |
| Author | He, Fupo Ye, Jiandong |
| Author_xml | – sequence: 1 givenname: Fupo surname: He fullname: He, Fupo organization: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China – sequence: 2 givenname: Jiandong surname: Ye fullname: Ye, Jiandong email: jdye@scut.edu.cn organization: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China |
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| Keywords | Biodegradation Glycolic acid copolymer Biological properties Lactone copolymer Biodegradability Lactic acid copolymer calcium phosphate cement Calcium phosphate degradation Scaffold In vivo Lamellar structure PLGA cytocompatibility Biocompatibility Biomaterial Osteogenesis Biomedical engineering unidirectional lamellar pore |
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J Biomed Mater Res A 2007; 81: 781-790. 2009; 89 27 1995; 16 2004; 25 2000; 21 2002; 13 2008; 19 1993; 260 2000; 50 2000; 192–5 2008; 7 1998; 81 1999; 20 2008; 4 1998; 41 2005; 26 2004; 32 2004; 71 1989; 10 2002; 61 2002; 23 2008; 29 2006; 27 1997; 35 2007; 80 2011; 22 1988; 232 2007; 81 2009; 5 2005; 94 2008; 86 2001; 55 2005; 59 2001; 12 2001; 58 2003; 100 2010; 6 2003; 65 1971; 5 1996; 6 e_1_2_6_31_2 e_1_2_6_30_2 Markovic M (e_1_2_6_36_2) 2000; 192 e_1_2_6_18_2 e_1_2_6_19_2 Yoshikawa T (e_1_2_6_35_2) 1996; 6 e_1_2_6_12_2 e_1_2_6_13_2 e_1_2_6_34_2 e_1_2_6_10_2 e_1_2_6_33_2 e_1_2_6_11_2 e_1_2_6_32_2 Eggli PS (e_1_2_6_4_2) 1988; 232 e_1_2_6_16_2 e_1_2_6_39_2 e_1_2_6_17_2 e_1_2_6_38_2 e_1_2_6_14_2 e_1_2_6_37_2 e_1_2_6_15_2 e_1_2_6_42_2 e_1_2_6_20_2 Yang F (e_1_2_6_8_2); 27 e_1_2_6_41_2 e_1_2_6_40_2 e_1_2_6_7_2 e_1_2_6_9_2 e_1_2_6_29_2 e_1_2_6_3_2 e_1_2_6_6_2 e_1_2_6_5_2 e_1_2_6_24_2 e_1_2_6_23_2 e_1_2_6_2_2 e_1_2_6_22_2 e_1_2_6_21_2 e_1_2_6_28_2 e_1_2_6_43_2 e_1_2_6_27_2 e_1_2_6_44_2 e_1_2_6_26_2 e_1_2_6_45_2 e_1_2_6_25_2 e_1_2_6_46_2 |
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| Snippet | The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic‐co‐glycolic acid) (PLGA)/calcium... The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic‐ co ‐glycolic acid)... The aim of this study was to investigate the in vitro degradation, cytocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid) (PLGA)/calcium... |
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| SubjectTerms | Alkaline phosphatase Animals Biocompatibility Biocompatible Materials - pharmacology Biological and medical sciences Biomedical materials Bone Cements - pharmacology calcium phosphate cement Calcium phosphates Calcium Phosphates - pharmacology Cell culture Cell differentiation Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Cement Compressive Strength - drug effects cytocompatibility Degradability Degradation Femur - drug effects Femur - pathology Glycolic acid Hydrogen-Ion Concentration - drug effects In vivo methods and tests Lactic Acid - pharmacology Lamellar structure Materials Testing - methods Mechanical properties Medical sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - enzymology Mesenchyme Microscopy, Electron, Scanning Microscopy, Fluorescence Orthopedic surgery Osteogenesis Osteogenesis - drug effects PLGA Polyglycolic Acid - pharmacology Polylactide-co-glycolide Porosity Prolongation Rabbits Rats scaffold Scaffolds Stem cell transplantation Stem cells Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical implants Technology. Biomaterials. Equipments Time Factors Tissue engineering Tissue Scaffolds - chemistry unidirectional lamellar pore |
| Title | In vitro degradation, biocompatibility, and in vivo osteogenesis of poly(lactic-co-glycolic acid)/calcium phosphate cement scaffold with unidirectional lamellar pore structure |
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