Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

• Published in: Molecular nutrition & food research Vol. 63; no. 18; pp. e1900177 - n/a
• Main Authors: Low, Dorrain Yanwen, Lefèvre‐Arbogast, Sophie, González‐Domínguez, Raúl, Urpi‐Sarda, Mireia, Micheau, Pierre, Petera, Melanie, Centeno, Delphine, Durand, Stephanie, Pujos‐Guillot, Estelle, Korosi, Aniko, Lucassen, Paul J, Aigner, Ludwig, Proust‐Lima, Cécile, Hejblum, Boris P, Helmer, Catherine, Andres‐Lacueva, Cristina, Thuret, Sandrine, Samieri, Cécilia, Manach, Claudine
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2019; Wiley-VCH Verlag; John Wiley and Sons Inc
• Subjects: Aged; Aged, 80 and over; Aging; Apolipoprotein E; Arginine; Biomarkers; Blood - metabolism; Blood Chemical Analysis; Case-Control Studies; Cocoa; Coffea; Coffee; Cognitive ability; cognitive decline; Cognitive Dysfunction - blood; Cognitive Dysfunction - metabolism; Creatinine; Dementia - blood; Dementia - metabolism; Dementia disorders; Diabetes mellitus; Diet; dietary biomarkers; Eating; Education; Female; Fish; Fish Products; Food and Nutrition; Humans; Hydrocortisone; Life Sciences; Longitudinal Studies; Male; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; Performance prediction; Prediction models; untargeted metabolomics; Wine; untargeted metabolomics; aging; cognitive decline; dietary biomarkers; coffee; Cognitive decline; Aging; Coffee; Dietary biomarkers; Untargeted metabolomics

Scope Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years and initially free of dementia. A total of 209 cases of cogni...