Human cellular differences in cAMP - CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder

• Published in: The European journal of neuroscience Vol. 40; no. 1; pp. 2206 - 2215
• Main Authors: Gaspar, Ludmila, van de Werken, Maan, Johansson, Anne-Sophie, Moriggi, Ermanno, Owe-Larsson, Björn, Kocks, Janwillem W. H., Lundkvist, Gabriella B., Gordijn, Marijke C. M., Brown, Steven A.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.07.2014; Blackwell
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; bipolar disorder; Bipolar Disorder - metabolism; Bipolar disorders; cAMP-CREB; Cells, Cultured; Chronobiology; circadian; Cohort Studies; Cyclic AMP - metabolism; Cyclic AMP Response Element-Binding Protein - metabolism; European Continental Ancestry Group; Female; fibroblast; Fibroblasts - metabolism; Fundamental and applied biological sciences. Psychology; Genetic Vectors; Humans; inter-individual differences; Lentivirus - genetics; Light; Male; Medical sciences; melatonin; Melatonin - metabolism; Middle Aged; Mood disorders; Photic Stimulation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Signal Transduction; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Mood disorder; Human; Melatonin; Cyclic AMP; Bipolar disorder; Biological rhythm; Circadian rhythm; Signal transduction; circadian; inter-individual differences; cAMP-CREB; Transcription factor CREB; Fibroblast; Pineal hormone; bipolar disorder; fibroblast; melatonin

Various lines of evidence suggest a mechanistic role for altered cAMP‐CREB (cAMP response element ‐ binding protein) signaling in depressive and affective disorders. However, the establishment and validation of human inter‐individual differences in this and other major signaling pathways has proven...