Human cellular differences in cAMP - CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder - Gaspar, Ludmila; van de Werken, Maan; Johansson, Anne-Sophie; Moriggi, Ermanno; Owe-Larsson, Björn; Kocks, Janwillem W. H.; Lundkvist, Gabriella B.; Gordijn, Marijke C. M.; Brown, Steven A. (The European journal of neuroscience, 2014)
Keywords: Adult; Adult and adolescent clinical studies; Biological and medical sciences; bipolar disorder; Bipolar Disorder - metabolism; Bipolar disorders; cAMP-CREB; Cells, Cultured; Chronobiology; circadian; Cohort Studies; Cyclic AMP - metabolism; Cyclic AMP Response Element-Binding Protein - metabolism; European Continental Ancestry Group; Female; fibroblast; Fibroblasts - metabolism; Fundamental and applied biological sciences. Psychology; Genetic Vectors; Humans; inter-individual differences; Lentivirus - genetics; Light; Male; Medical sciences; melatonin; Melatonin - metabolism; Middle Aged; Mood disorders; Photic Stimulation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Signal Transduction; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Mood disorder; Human; Melatonin; Cyclic AMP; Bipolar disorder; Biological rhythm; Circadian rhythm; Signal transduction; circadian; inter-individual differences; cAMP-CREB; Transcription factor CREB; Fibroblast; Pineal hormone; bipolar disorder; fibroblast; melatonin