Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis

• Published in: Journal of clinical pharmacology Vol. 47; no. 12; p. 1466
• Main Authors: Chen, Nianhang, Lau, Henry, Kong, Linghui, Kumar, Gondi, Zeldis, Jerome B, Knight, Robert, Laskin, Oscar L
• Format: Journal Article
• Language: English
• Published: England 01.12.2007
• Subjects: Administration, Oral; Adult; Aged; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; Area Under Curve; Disease Progression; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Kidney - metabolism; Kidney - pathology; Kidney - physiopathology; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - therapy; Male; Metabolic Clearance Rate; Middle Aged; Renal Dialysis; Severity of Illness Index; Stereoisomerism; Tandem Mass Spectrometry; Thalidomide - analogs & derivatives; Thalidomide - chemistry; Thalidomide - pharmacokinetics

The present study investigated the effect of renal impairment and hemodialysis on the pharmacokinetics of lenalidomide following a single 25-mg oral dose in 30 subjects aged 39 to 76 years. A single 25-mg dose was well tolerated by renally impaired subjects. Renal impairment did not alter the oral a...