Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study

• Published in: British journal of clinical pharmacology Vol. 66; no. 5; pp. 695 - 705
• Main Authors: Diav‐Citrin, Orna, Shechtman, Svetlana, Weinbaum, Dafna, Wajnberg, Rebecka, Avgil, Meytal, Di Gianantonio, Elena, Clementi, Maurizio, Weber‐Schoendorfer, Corinna, Schaefer, Christof, Ornoy, Asher
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2008; Blackwell Science Inc
• Subjects: Abnormalities, Drug-Induced - etiology; Abortion, Induced; Adult; Antidepressive Agents, Second-Generation - adverse effects; Antidepressive Agents, Second-Generation - therapeutic use; Birth Weight; cardiovascular anomalies; Case-Control Studies; Confidence Intervals; congenital anomalies; Drug Administration Schedule; Drugs in Pregnancy and Lactation; Female; fluoxetine; Fluoxetine - adverse effects; Fluoxetine - therapeutic use; Gestational Age; Heart Defects, Congenital - etiology; Humans; Infant, Newborn; Maternal Age; Odds Ratio; paroxetine; Paroxetine - adverse effects; Paroxetine - therapeutic use; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Risk; Selective Serotonin Reuptake Inhibitors - adverse effects; Selective Serotonin Reuptake Inhibitors - therapeutic use; SSRI

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In recent years there has been concern regarding the possibility that selective serotonin reuptake inhibitors (SSRIs) cause an increased rate of congenital cardiovascular anomalies. • As of today, there is still debate in the literature as to the possible e...