The first example of a paraben-dependent antibody to an Rh protein

• Published in: Transfusion (Philadelphia, Pa.) Vol. 41; no. 3; pp. 371 - 374
• Main Authors: Judd, W. John, Storry, Jill R., Annesley, Thomas D., Reid, Marion E., Bensette, Michelle, Waddington, Sherry, Dake, LouAnn, Rohrkemper, David, Valdez, Ricardo
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.03.2001; Blackwell Publishing
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; C-LISS = commercial LISS; Erythrocytes - immunology; Female; Humans; Isoantibodies - analysis; Kidd Blood-Group System - immunology; Medical sciences; Parabens - adverse effects; Parabens - chemistry; Pregnancy; Rho(D) Immune Globulin - immunology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; UMHS = University of Michigan Health Systems; Benzoic acid; Case study; Human; Hematology; Antibody; Female; Rh-System

BACKGROUND: Parabens are added to a commercial LISS (C‐LISS) to retard microbial growth. Paraben‐dependent anti‐Jka has been detected by the use of C‐LISS. CASE REPORT: Serum from a D+ woman reacted in antiglobulin tests with RBCs stored (2‐4 hours, 22‐25°C) in C‐LISS (Löw and Messeter formulation,...