The first observation of osmotically neutral sodium accumulation in the myocardial interstitium

The aim of this study was the detection and quantification of the Na depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluoresce...

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Published inScientific reports Vol. 11; no. 1; p. 22025
Main Authors Artyukov, I, Arutyunov, G, Bobrov, M, Bukreeva, I, Cedola, A, Dragunov, D, Feshchenko, R, Fratini, M, Mitrokhin, V, Sokolova, A, Vinogradov, A, Gianoncelli, A
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 11.11.2021
Nature Publishing Group UK
Nature Portfolio
Subjects
Animals
Comparative analysis
Extracellular matrix
Extracellular Matrix - metabolism
Glycosaminoglycans
Glycosaminoglycans - metabolism
Male
Myocardium - metabolism
Osmosis
Rats
Rats, Wistar
Sodium
Sodium - metabolism
X-ray fluorescence
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Summary:The aim of this study was the detection and quantification of the Na depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluorescence (XRF) spectromicroscopy technique used to perform a comparative analysis of sodium containment in intracellular and interstitial spaces of cardiac tissues taken from animals selected by low and high sodium intake rates. The experimental results obtained show that high sodium daily intake can result in a remarkable increase of sodium content in the myocardial interstitium.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-01443-8