Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor

• Published in: Scientific reports Vol. 11; no. 1; p. 7944
• Main Authors: Mohamed, Fatma El Zahraa A, Abdelaziz, Ali Omar, Kasem, Ahmed Hussein, Ellethy, Tarek, Gayyed, Mariana F
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 12.04.2021; Nature Publishing Group UK; Nature Portfolio
• Subjects: Adenocarcinoma; Biomarkers, Tumor - metabolism; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Squamous Cell - pathology; Chemotherapy; DNA microarrays; Female; Gene expression; Hormones; Humans; Immunohistochemistry; Inflammation; Lung cancer; Lung carcinoma; Lung Neoplasms - diagnosis; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; Middle Aged; Multivariate Analysis; Non-small cell lung carcinoma; Prognosis; Proportional Hazards Models; Small cell lung carcinoma; Squamous cell carcinoma; Survival Analysis; Therapeutic applications; Thyroid; Thyroid gland; Thyroid hormone receptors; Thyroid Hormone Receptors alpha - metabolism; Thyroid hormones; Tumors

Lung cancer is considered the major cause of cancer-related deaths worldwide. Unfortunately, all chemotherapy regimens used in lung cancer treatment showed nearly the same efficacy. Finding a new therapeutic target that can be used as an alternative after the failure of or in association with chemot...