Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain

• Published in: Cell death & disease Vol. 11; no. 9; p. 747
• Main Authors: Ma, Xiaqing, Du, Wenjie, Wang, Wenying, Luo, Limin, Huang, Min, Wang, Haiyan, Lin, Raozhou, Li, Zhongping, Shi, Haibo, Yuan, Tifei, Jiang, Wei, Worley, Paul F, Xu, Tao
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 12.09.2020; Nature Publishing Group UK
• Subjects: Animals; Brain slice preparation; Cell cycle; Disease Models, Animal; Firing rate; Hypersensitivity; Ion channels (cyclic nucleotide-gated); Localization; Male; Mechanistic Target of Rapamycin Complex 1 - metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Neuralgia; Neuralgia - metabolism; Neuralgia - pathology; Neurons - metabolism; Neurons - pathology; Pain; Phenotypes; Phosphorylation; Rapamycin; Ras Homolog Enriched in Brain Protein - metabolism; Signal Transduction; Spinal cord; Spinal Cord - metabolism; Spinal Cord - pathology; TOR protein; TOR Serine-Threonine Kinases - metabolism

The small GTPase Ras homolog enriched in the brain (Rheb) can activate mammalian target of rapamycin (mTOR) and regulate the growth and cell cycle progression. We investigated the role of Rheb-mediated mTORC1 signaling in neuropathic pain. A chronic constriction injury (CCI) model was dopted. CCI in...