Mutation Analysis of Consanguineous Moroccan Patients with Parkinson's Disease Combining Microarray and Gene Panel

• Published in: Frontiers in neurology Vol. 8; p. 567
• Main Authors: Bouhouche, Ahmed, Tesson, Christelle, Regragui, Wafaa, Rahmani, Mounia, Drouet, Valérie, Tibar, Houyam, Souirti, Zouhayr, Ben El Haj, Rafiqua, Bouslam, Naima, Yahyaoui, Mohamed, Brice, Alexis, Benomar, Ali, Lesage, Suzanne
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media 31.10.2017; Frontiers Media S.A
• Subjects: chromosomal microarray analysis; consanguinity; Life Sciences; Moroccan patients; Neurons and Cognition; Neuroscience; next-generation sequencing gene panel; Parkinson’s disease; Moroccan patients; consanguinity; Parkinson’s disease; chromosomal microarray analysis; next-generation sequencing gene panel; Parkinson's disease; next- generation sequencing gene panel

During the last two decades, 15 different genes have been reported to be responsible for the monogenic form of Parkinson's disease (PD), representing a worldwide frequency of 5-10%. Among them, 10 genes have been associated with autosomal recessive PD, with and being the most frequent. In a coh...