Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women

• Published in: Environmental research Vol. 151; pp. 30 - 37
• Main Authors: Aker, Amira M., Watkins, Deborah J., Johns, Lauren E., Ferguson, Kelly K., Soldin, Offie P., Anzalota Del Toro, Liza V., Alshawabkeh, Akram N., Cordero, José F., Meeker, John D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2016
• Subjects: Adolescent; Adult; Biomarkers - blood; Biomarkers - urine; Environmental Monitoring; Environmental Pollutants - urine; Female; Hormones - blood; Humans; Parabens; Parabens - analysis; Phenols; Phenols - urine; Pregnancy; Prospective Studies; Puerto Rico; Reproductive hormones; Thyroid hormones; Young Adult; ASW, Caribbean Sea, Greater Antilles, Puerto Rico; PPB; TCS; E/P; Ft4; EDCs; PROTECT; 2,5-DCP; Reproductive hormones; SG; GSD; Thyroid hormones; LOD; 2,4-DCP; FT3; GM; TSH; BP-3; IQR; ER; Parabens; Pregnancy; BPA; BPB; Phenols; NHANES; SHBG; MPB
• DOI: 10.1016/j.envres.2016.07.002
• ISSN: 0013-9351

Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the prospective cohort, “Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)”. Urinary exposure biomarkers (bisphenol A, triclosan, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, butyl, methyl and propyl paraben) and serum hormone levels (estradiol, progesterone, sex hormone-binding globulin (SHBG), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone) were measured at up to two time points during pregnancy (16–20 weeks and 24–28 weeks). We used linear mixed models to assess relationships between exposure biomarkers and hormone levels across pregnancy, controlling for urinary specific gravity, maternal age, BMI and education. In sensitivity analyses, we evaluated cross-sectional relationships between exposure and hormone levels stratified by study visit using linear regression. An IQR increase in methyl paraben was associated with a 7.70% increase (95% CI 1.50, 13.90) in SHBG. Furthermore, an IQR increase in butyl paraben as associated with an 8.46% decrease (95% CI 16.92, 0.00) in estradiol, as well as a 9.34% decrease (95% CI −18.31,−0.38) in estradiol/progesterone. Conversely, an IQR increase in butyl paraben was associated with a 5.64% increase (95% CI 1.26, 10.02) in FT4. Progesterone was consistently negatively associated with phenols, but none reached statistical significance. After stratification, methyl and propyl paraben were suggestively negatively associated with estradiol at the first time point (16–20 weeks), and suggestively positively associated with estradiol at the second time point (24–28 weeks). Within this ongoing birth cohort, certain phenols and parabens were associated with altered reproductive and thyroid hormone levels during pregnancy. These changes may contribute to adverse health effects in mothers or their offspring, but additional research is required. •Phenol/paraben biomarkers were measured at two time points in pregnant women.•Certain exposures were associated to changes in reproductive/thyroid hormone levels.•Some differences in the associations were observed between time points in pregnancy.