Identification of Four Novel Loci in Asthma in European American and African American Populations

• Published in: American journal of respiratory and critical care medicine Vol. 195; no. 4; pp. 456 - 463
• Main Authors: Almoguera, Berta, Vazquez, Lyam, Mentch, Frank, Connolly, John, Pacheco, Jennifer A., Sundaresan, Agnes S., Peissig, Peggy L., Linneman, James G., McCarty, Catherine A., Crosslin, David, Carrell, David S., Lingren, Todd, Namjou-Khales, Bahram, Harley, John B., Larson, Eric, Jarvik, Gail P., Brilliant, Murray, Williams, Marc S., Kullo, Iftikhar J., Hysinger, Erik B., Sleiman, Patrick M. A., Hakonarson, Hakon
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.02.2017
• Subjects: Adolescent; Adult; African Americans - genetics; Airway Remodeling - genetics; Airway Remodeling - immunology; Algorithms; Asthma - ethnology; Asthma - genetics; Child; Child, Preschool; Data Mining - methods; Electronic Health Records - statistics & numerical data; European Continental Ancestry Group - genetics; Female; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; Humans; Male; Meta-Analysis as Topic; Original; Phenotype; Prevalence; Prostaglandin-E Synthases - genetics; United States; asthma; genetics; genome-wide association study

Despite significant advances in knowledge of the genetic architecture of asthma, specific contributors to the variability in the burden between populations remain uncovered. To identify additional genetic susceptibility factors of asthma in European American and African American populations. A pheno...