Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 318; no. 1; pp. L78 - L88
• Main Authors: Moskowitzova, Kamila, Orfany, Arzoo, Liu, Kaifeng, Ramirez-Barbieri, Giovanna, Thedsanamoorthy, Jerusha K., Yao, Rouan, Guariento, Alvise, Doulamis, Ilias P., Blitzer, David, Shin, Borami, Snay, Erin R., Inkster, James A. H., Iken, Khadija, Packard, Alan B., Cowan, Douglas B., Visner, Gary A., del Nido, Pedro J., McCully, James D.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2020
• Subjects: Acute Lung Injury - metabolism; Acute Lung Injury - physiopathology; Animals; Apoptosis; Apoptosis - physiology; Bronchoalveolar Lavage Fluid; Chemokines; Chemokines - metabolism; Cytokines; Cytokines - metabolism; Damage; Damping capacity; Disease Models, Animal; Edema; Injuries; Ischemia; Lung - metabolism; Lung - physiopathology; Lung transplants; Lungs; Male; Mechanics; Mechanics (physics); Mice; Mice, Inbred C57BL; Microvasculature; Mitochondria; Mitochondria - metabolism; Mitochondria - physiology; Muscles; Neutrophil Infiltration - physiology; Ostomy; Pressure; Pulmonary arteries; Pulmonary artery; Recovery; Reperfusion; Reperfusion Injury - metabolism; Reperfusion Injury - physiopathology; Respiration; Respiratory Function Tests - methods; Trachea; Transplantation; Transplants & implants; Viability; ischemia-reperfusion injury; acute lung injury; mitochondrial transplantation

The most common cause of acute lung injury is ischemia-reperfusion injury (IRI), during which mitochondrial damage occurs. We have previously demonstrated that mitochondrial transplantation is an efficacious therapy to replace or augment mitochondria damaged by IRI, allowing for enhanced muscle viab...