Prolonged evolution of the human B cell response to SARS-CoV-2 infection

• Published in: Science immunology Vol. 6; no. 56
• Main Authors: Sakharkar, Mrunal, Rappazzo, C Garrett, Wieland-Alter, Wendy F, Hsieh, Ching-Lin, Wrapp, Daniel, Esterman, Emma S, Kaku, Chengzi I, Wec, Anna Z, Geoghegan, James C, McLellan, Jason S, Connor, Ruth I, Wright, Peter F, Walker, Laura M
• Format: Journal Article
• Language: English
• Published: United States 23.02.2021
• Subjects: Adult; Aged; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; B-Lymphocytes - immunology; Binding Sites; Cohort Studies; COVID-19 - immunology; COVID-19 - virology; Cross Reactions; Female; Humans; Immunologic Memory; Longitudinal Studies; Male; Middle Aged; SARS-CoV-2 - immunology

A comprehensive understanding of the kinetics and evolution of the human B cell response to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and therapies. Here, we longitudinally profiled this response in mild and severe COVID-19 patients over a period of five months...